Multiple cerebral infarctions after intravenous immunoglobulin for Guillain-Barré syndrome: two case reports and review of the literature

被引:0
|
作者
Wang, Weisen [1 ,2 ]
Feng, Chunhua [1 ]
Liu, Yanqun [1 ]
Tao, Yi [1 ]
Bi, Xiaoying [1 ]
Hou, Xiaojun [1 ]
机构
[1] Naval Med Univ, Dept Neurol, Affiliated Hosp 1, Shanghai, Peoples R China
[2] 983rd Hosp Joint Logist Support Forces PLA, Dept Neurol, Tianjin, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
Guillain-Barr & eacute; syndrome; multiple cerebral infarctions; intravenous immunoglobulin; acute bulbar palsy; vascular risk factor; IMMUNE GLOBULIN; THERAPY; RISK; PATIENT; STROKES; EVENTS; DEATH;
D O I
10.3389/fimmu.2024.1433240
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background Guillain-Barr & eacute; syndrome (GBS) is a polyradiculoneuropathy mediated by the immune system and is the primary reason for acute flaccid paralysis. Intravenous immunoglobulin (IVIg) is a recognized immunotherapeutic drug that can accelerate recovery from GBS. Limited literature exists concerning cerebral infarction complications with IVIg following its use in the treatment of GBS.Case presentation A patient was diagnosed with the acute inflammatory demyelinating polyradiculoneuropathy subtype of GBS, while another patient was diagnosed with the acute bulbar palsy variant of GBS 2 years prior and experienced a relapse of GBS. Both patients received immunoglobulin therapy, during which multiple acute cerebral infarctions were detected using magnetic resonance imaging. Both patients had a history of coronary artery atherosclerotic heart disease and vertebral artery stenosis, and D-dimer and fibrinogen degradation products were significantly elevated after immunoglobulin therapy.Conclusions The risk of cerebral infarction associated with IVIg is generally low in patients with different GBS variants. Nevertheless, the occurrence of cerebral infarction associated with IVIg might not be insignificant in older patients with vascular risk factors and should be carefully monitored.
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页数:7
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