Nintedanib Alters Fibroblast and Macrophage Diversity in a 3D Skin Model of Systemic Sclerosis (SSc)

被引:0
|
作者
Kosarek, Noelle [1 ]
Abel, Tamar [2 ]
Shenk, Sasha [3 ]
Wood, Tammara [2 ]
Garlick, Jonathan [4 ]
Pioli, Patricia [5 ]
Whitfield, Michael [5 ]
机构
[1] Dartmouth Geisel Sch Med, Lebanon, NH USA
[2] Dartmouth Coll, Hanover, NH 03755 USA
[3] Tufts Univ, Boston, MA 02111 USA
[4] Tufts Univ, Sch Dent Med, Boston, MA 02111 USA
[5] Geisel Sch Med Dartmouth, Hanover, NH USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
0948
引用
收藏
页码:1866 / 1867
页数:2
相关论文
共 50 条
  • [1] Nintedanib inhibits fibroblast activation and ameliorates pulmonary and dermal fibrosis in models of systemic sclerosis (SSc)
    Huang, Jingang
    Beyer, Christian
    Palumbo-Zerr, Katrin
    Zhang, Yun
    Wollin, Stefan-Lutz
    Distler, Joerg
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [2] Single Cell RNA-sequencing Identifies Distinct Fibroblast Subsets in a Human 3D Skin Model of Systemic Sclerosis
    Kosarek, Noelle Noreen
    Wheeler, Tamar
    Toledo, Diana Maria
    Huang, Mengqi
    Pioli, Patricia A.
    Whitfield, Michael
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [3] Identification of Distinct Fibroblast Populations in Systemic Sclerosis 3D Skin Tissues with Single Cell Omics
    Kosarek, Noelle
    Yang, Heetaek
    Kolling, Fred W.
    Abel, Tamar
    Huang, Mengqi
    Smith, Avi
    Garlick, Jonathan
    Pioli, Patricia A.
    Whitfield, Michael L.
    ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 3013 - 3014
  • [4] Monocytes drive myofibroblast contraction in a 3D skin model used to understand fibrosis in systemic sclerosis
    da Silva, Djulio Zanin
    van Kooten, Nienke
    Papadimitriou, Theogiannis
    Dorst, Daphne
    Walgreen, Birgitte
    Vitters, Elly
    van der Kraan, Peter
    van den Bosch, Martijn
    van Caam, Arjan
    Koenders, Marije
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 818 - 818
  • [5] Characteristics and impact of infiltration of B-cells from systemic sclerosis patients in a 3D healthy skin model
    Le Maitre, Mathilde
    Guerrier, Thomas
    Collet, Aurore
    Derhourhi, Mehdi
    Meneboo, Jean-Pascal
    Toussaint, Benedicte
    Bonnefond, Amelie
    Villenet, Celine
    Sebda, Sheherazade
    Bongiovanni, Antonino
    Tardivel, Meryem
    Simon, Myriam
    Jendoubi, Manel
    Daunou, Blanche
    Largy, Alexis
    Figeac, Martin
    Dubucquoi, Sylvain
    Launay, David
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [6] EFFECTS OF NINTEDANIB IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED ILD (SSC-ILD) AND DIFFERING EXTENTS OF SKIN FIBROSIS: FURTHER ANALYSES OF THE SENSCIS TRIAL
    Allanore, Y.
    Steen, V.
    Kuwana, M.
    Denton, C.
    Matucci-Cerinic, M.
    Volkmann, E.
    Khanna, D.
    Wachtlin, D.
    Gahlemann, M.
    Quaresma, M.
    Alves, M.
    Distler, O.
    ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 391 - 392
  • [7] Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis
    Huang, Jingang
    Maier, Christiane
    Zhang, Yun
    Soare, Alina
    Dees, Clara
    Beyer, Christian
    Harre, Ulrike
    Chen, Chih-Wei
    Distler, Oliver
    Schett, Georg
    Wollin, Lutz
    Distler, Joerg H. W.
    ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (11) : 1941 - +
  • [8] Monocyte chemoattractant protein (MCP) -1, -2 and -3 in the skin of patients with progressive systemic sclerosis (SSc)
    Distler, O
    Pap, T
    Schmidt, C
    Rinkes, B
    Hohenleutner, U
    Landthaler, M
    Schölmerich, J
    Lang, B
    Gay, RE
    Müller-Ladner, U
    Gay, S
    ARTHRITIS AND RHEUMATISM, 1998, 41 (09): : S322 - S322
  • [9] THE COURSE OF SKIN INVOLVEMENT IN SYSTEMIC-SCLEROSIS (SSC) OVER 3 YEARS - THE CHLORAMBUCIL VS PLACEBO TRIAL
    CLEMENTS, PJ
    LACHENBRUCH, PA
    FURST, DE
    PAULUS, HE
    ARTHRITIS AND RHEUMATISM, 1993, 36 (09): : S131 - S131
  • [10] VASCULARIZED 3D IN VITRO SKIN MODEL
    Singh, Smriti
    TISSUE ENGINEERING PART A, 2023, 29 (11-12) : 1041 - 1041