Molecular Pathways Regulating Circadian Rhythm and Associated Diseases

被引：0

作者：

Ding, Min ^{[1
,2
,3
,4
,5
]}

Zhou, Hang ^{[1
,2
]}

Li, Yu-Mei ^{[1
,2
]}

Zheng, Yun-Wen ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Inst Regenerat Med, Zhenjiang 212001, Peoples R China

[2] Jiangsu Univ, Affiliated Hosp, Dept Dermatol, Zhenjiang 212001, Peoples R China

[3] Guangdong Prov Key Lab Large Anim Models Biomed, Jiangmen 529020, Peoples R China

[4] South China Inst Large Anim Models Biomed, Jiangmen 529020, Peoples R China

[5] Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Guangdong, Peoples R China

[6] Tokyo Univ Sci, Fac Pharmaceut Sci, Dept Med & Life Sci, Chiba 2788510, Japan

[7] Univ Tokyo, Inst Med Sci, Ctr Stem Cell Biol & Regenerat Med, Tokyo 1088639, Japan

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2024年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

circadian rhythm; retinal ganglion cells; melanocytes; photoneuroendocrinology; genetic clock; BMAL1; liver fatty; T2DM; phototherapy; GLUCOSE-METABOLISM; MELATONIN SECRETION; INSULIN-RESISTANCE; BRIGHT LIGHT; SLEEP; CLOCK; DISRUPTION; HEALTH; CONSEQUENCES; SENSITIVITY;

D O I：

10.31083/j.fbl2906206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circadian rhythms, the natural cycles of physical, mental, and behavioral changes that follow a roughly 24 -hour cycle, are known to have a profound effect on the human body. Light plays an important role in the regulation of circadian rhythm in human body. When light from the outside enters the eyes, cones, rods, and specialized retinal ganglion cells receive the light signal and transmit it to the suprachiasmatic nucleus of the hypothalamus. The central rhythm oscillator of the suprachiasmatic nucleus regulates the rhythm oscillator of tissues all over the body. Circadian rhythms, the natural cycles of physical, mental, and behavioral changes that follow a roughly 24 -hour cycle, are known to have a profound effect on the human body. As the largest organ in the human body, skin plays an important role in the peripheral circadian rhythm regulation system. Like photoreceptor cells in the retina, melanocytes express opsins. Studies show that melanocytes in the skin are also sensitive to light, allowing the skin to "see" light even without the eyes. Upon receiving light signals, melanocytes in the skin release hormones that maintain homeostasis. This process is called "photoneuroendocrinology", which supports the health effects of light exposure. However, inappropriate light exposure, such as prolonged work in dark environments or exposure to artificial light at night, can disrupt circadian rhythms. Such disruptions are linked to a variety of health issues, emphasizing the need for proper light management in daily life. Conversely, harnessing light's beneficial effects through phototherapy is gaining attention as an adjunctive treatment modality. Despite these advancements, the field of circadian rhythm research still faces several unresolved issues and emerging challenges. One of the most exciting prospects is the use of the skin's photosensitivity to treat diseases. This approach could revolutionize how we think about and manage various health conditions, leveraging the skin's unique ability to respond to light for therapeutic purposes. As research continues to unravel the complexities of circadian rhythms and their impact on health, the potential for innovative treatments and improved wellbeing is immense.

引用

页数：11