First pregnancy and live birth from ex vivo-retrieved metaphase II oocytes from a woman with bilateral ovarian carcinoma: a case report

Objective: To report pregnancy and live birth resulting from intracytoplasmic sperm injection of ex vivo -retrieved mature oocytes from a woman with bilateral ovarian carcinoma. Design: Case report. Setting: Fertility clinic. Patient: A 34 -year -old nulliparous woman with bilateral ovarian tumor, with a risk of malignancy of 96.1% according to International Ovarian Tumor Analysis Group recommendations for adnexal tumors, who desired fertility preservation before de fi nitive surgical treatment. Intervention(s): Cryopreservation of ex vivo -retrieved mature metaphase II oocytes is followed by fertilization with donor sperm and embryo transfer to a gestational carrier. Main Outcome Measure(s): Fertility preservation. Results: After controlled ovarian stimulation, 12 metaphase II oocytes were retrieved from oophorectomized specimens and vitri fi ed. Intracytoplasmic sperm injection with donor sperm was performed in remission, resulting in 9 cleavage -stage embryos, 2 of which were transferred to a gestational carrier, resulting in a normal, healthy singleton pregnancy, and the live birth of a healthy infant. Conclusion(s): Ex vivo oocyte retrieval after oophorectomy may be a safe alternative to standard oocyte retrieval for fertility preservation in women with ovarian malignancies. (Fertil Steril e 2024;121:1031 - 9. (c) 2024 by American Society for Reproductive Medicine.) El resumen est & aacute; disponible en Espa & ntilde;ol al final del art & iacute;culo.