Design, synthesis and biological evaluation of isoxazole bearing N-Arylpyrazole derivatives as anticancer agents

A novel library of isoxazole bearing N-arylpyrazole (12a -j) derivatives has been designed synthesized and their structures were confirmed by 1HNMR, 13CNMR and mass spectral analysis. Further, these compounds were evaluated for their anticancer activity towards four human cancer cell line including MCF-7: human breast, A549: human lung, DU -145: human prostrate and MDA MB -231: human breast) and etoposide used standard drug. Most of the synthesized compounds showed good to moderate activity. Among them, these compounds 12b, 12c, 12d, 12f, 12g and 12h displayed more potent than etoposide. Particularly, compound 12h has showed most promising activity compare to all compounds (MCF-7 = 0.31 +/- 0.044 mu M, A549 = 0.47 +/- 0.059 mu M, Du -145 = 0.19 +/- 0.053 mu M and MDA MB -231 = 0.37 +/- 0.098 mu M)