Fungal infection frequency in newly diagnosed acute myeloid leukaemia patients treated with venetoclax plus azacitidine with or without antifungal prophylaxis

被引：1

作者：

Weinbergerova, Barbora ^{[1
,2
]}

Mayer, Jiri ^{[1
,2
]}

Kabut, Tomas ^{[1
,2
]}

Sperr, Wolfgang R. ^{[3
,4
]}

Stevkova, Jana ^{[5
]}

Jonasova, Anna ^{[6
]}

Cernan, Martin ^{[7
,8
]}

Herndlhofer, Susanne ^{[3
]}

Oravcova, Iveta ^{[9
,10
]}

Sramek, Jiri ^{[11
]}

Novak, Jan ^{[12
,13
]}

Stepanova, Radka ^{[14
]}

Szotkowski, Tomas ^{[7
,8
]}

Drgona, Lubos ^{[9
,10
]}

Zak, Pavel ^{[5
]}

Valent, Peter ^{[3
,4
]}

机构：

[1] Masaryk Univ, Dept Internal Med Hematol & Oncol, Jihlavska 20, Brno 62500, Czech Republic

[2] Univ Hosp Brno, Jihlavska 20, Brno 62500, Czech Republic

[3] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria

[4] Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria

[5] Univ Hosp Hradec Kralove, Dept Internal Med Hematol 4, Hradec Kralove, Czech Republic

[6] Charles Univ Prague, Gen Hosp, Med Dept, Hematol, Prague, Czech Republic

[7] Palacky Univ Olomouc, Fac Med & Dent, Dept Hemato Oncol, Olomouc, Czech Republic

[8] Univ Hosp Olomouc, Olomouc, Czech Republic

[9] Comenius Univ, Dept Oncohematol, Bratislava, Slovakia

[10] Natl Canc Inst, Bratislava, Slovakia

[11] Univ Hosp Plzen, Dept Haematol & Oncol, Plzen, Czech Republic

[12] Charles Univ Prague, Fac Med 3, Dept Haematol, Prague, Czech Republic

[13] Univ Hosp Kralovske Vinohrady, Prague, Czech Republic

[14] Masaryk Univ, Fac Med, Ctr Excellence CREAT, Brno, Czech Republic

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 05期

关键词：

acute myeloid leukaemia; antifungal prophylaxis; fungal infection; venetoclax and azacitidine;

D O I：

10.1111/bjh.19670

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our observational study analysed fungal infection frequency within cohorts with versus without antifungal prophylaxis (AFP) among newly diagnosed first-line venetoclax and azacitidine (VEN + AZA)-treated acute myeloid leukaemias in Czech, Austrian and Slovak haematology centres. Among 186 patients, 85 (46%) received antifungal prophylaxis, while 101 (54%) received no prophylaxis. Fungal infections occurred in 1/85 patients with prophylaxis (1%) and 5/101 patients without prophylaxis (5%) (p = 0.222). No significant difference was recorded between cohorts with and without AFP in terms of death rate (p = 0.296) and overall survival (p = 0.844). In conclusion, most infections were not severe, developing during the first treatment-cycle and did not affect patients' overall outcome.

引用

页码：1746 / 1750

页数：5

共 50 条

[1] Azacitidine and venetoclax with or without pevonedistat in patients with newly diagnosed acute myeloid leukemia
Short, Nicholas J.
Wierzbowska, Agnieszka
Cluzeau, Thomas
Laribi, Kamel
Recher, Christian
Czyz, Jaroslaw
Ochrem, Bogdan
Ades, Lionel
Gallego-Hernanz, Maria Pilar
Heiblig, Mael
Audisio, Ernesta
Zarzycka, Ewa
Li, Shuli
Ferenc, Nicholas
Yeh, Tammie
Faller, Douglas V.
Sedarati, Farhad
Papayannidis, Cristina
LEUKEMIA & LYMPHOMA, 2025, 66 (03) : 458 - 468
[2] Azacitidine Plus Venetoclax for the Treatment of Relapsed and Newly Diagnosed Acute Myeloid Leukemia Patients
Garciaz, Sylvain
Hospital, Marie-Anne
Alary, Anne-Sophie
Saillard, Colombe
Hicheri, Yosr
Mohty, Bilal
Rey, Jerome
D'Incan, Evelyne
Charbonnier, Aude
Villetard, Ferdinand
Maisano, Valerio
Lombardi, Laura
Ittel, Antoine
Mozziconacci, Marie-Joelle
Gelsi-Boyer, Veronique
Vey, Norbert
CANCERS, 2022, 14 (08)
[3] Combining azole antifungals with venetoclax plus azacitidine in patients with newly diagnosed acute myeloid leukemia
Zhong, Xushu
Wang, Jia
Dai, Yang
Huang, Xiaoou
Liu, Jiazhuo
Xiang, Bing
Ma, Hongbing
HEMATOLOGY, 2024, 29 (01)
[4] The propriety of upgrading responses to venetoclax plus azacitidine in newly diagnosed patients with acute myeloid leukemia
Abbott, Diana
Cherry, Evan
Amaya, Maria
McMahon, Christine
Schwartz, Marc
Winters, Amanda
Schowinsky, Jeffrey
Jordan, Craig T.
Smith, Clayton
Gutman, Jonathan A.
Pollyea, Daniel A.
LEUKEMIA & LYMPHOMA, 2021, 62 (06) : 1466 - 1473
[5] Cytopenia Management in Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax Plus Azacitidine in the VIALE-A Study
Pratz, Keith W.
DiNardo, Courtney D.
Selleslag, Dominik
Li, Junmin
Yamamoto, Kazuhito
Konopleva, Marina
McDonald, Andrew
Babu, Sunil
Stevens, Don A.
Kantarjian, Hagop M.
Traina, Fabiola
Venditti, Adriano
Mayer, Jiri
Montez, Melissa
Ramsingh, Giridharan
Jin, Huan
Ainsworth, William
Duan, Yinghui
Svensson, Anders Erik
Werner, Michael
Potluri, Jalaja
Jonas, Brian A.
BLOOD, 2020, 136
[6] Low-dose venetoclax combined with azacitidine in older and frail patients with newly diagnosed acute myeloid leukaemia
Rong, Chunmeng
Yang, Fang
Chen, Yalu
Wang, Ming
Ai, Cheng
Luo, Yuqing
Gao, Panpan
Weng, Yiqin
Huang, Xiaguang
Gu, Meier
Huang, Weiping
Xia, Yongming
ONCOLOGY LETTERS, 2024, 27 (05)
[7] Outcomes in Chemotherapy-Ineligible Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia Treated with Venetoclax Plus Azacitidine: A Pooled Analysis
Venditti, Adriano
Hou, Jing-Zhou
Fenaux, Pierre
Jonas, Brian A.
Vrhovac, Radovan
Montesinos, Pau
Garcia, Jacqueline S.
Rizzieri, David
Thirman, Michael J.
Kotey, Stanley
Potluri, Jalaja
Dhalla, Mazaher
Pullarkat, Vinod
BLOOD, 2023, 142
[8] Venetoclax and azacitidine compared with induction chemotherapy for newly diagnosed patients with acute myeloid leukemia
Cherry, Evan M.
Abbott, Diana
Amaya, Maria
McMahon, Christine
Schwartz, Marc
Rosser, Julie
Sato, Audrey
Schowinsky, Jeffrey
Inguva, Anagha
Minhajuddin, Mohd
Pei, Shanshan
Stevens, Brett
Winters, Amanda
Jordan, Craig T.
Smith, Clayton
Gutman, Jonathan A.
Pollyea, Daniel A.
BLOOD ADVANCES, 2021, 5 (24) : 5565 - 5573
[9] Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax
Chen, Evan C.
Liu, Yiwen
Harris, Courtney E.
Winer, Eric S.
Wadleigh, Martha
Lane, Andrew A.
Vedula, Rahul S.
Lindsley, R. Coleman
Copson, Kevin M.
Charles, Anne
Marty, Francisco
Neuberg, Donna
DeAngelo, Daniel J.
Stone, Richard M.
Luskin, Marlise R.
Issa, Nicolas C.
Garcia, Jacqueline S.
LEUKEMIA & LYMPHOMA, 2022, 63 (08) : 1934 - 1941
[10] Antifungal Prophylaxis in Newly Diagnosed Acute Myeloid Leukemia Treated with a Hypomethylating Agent and Venetoclax: A Real-World Experience in Pharmacovigilance
Burke, Mary
Sallman, David A.
Denson, Ariel
Nelson, Rebecca Jean
Chan, Onyee
Walker, Alison R.
Padron, Eric
Xie, Zhuoer
Komrokji, Rami S.
Lancet, Jeffrey
Kuykendall, Andrew T.
Tobon, Katherine
Jain, Akriti Gupta
Wang, Chen
Al Ali, Najla H.
BLOOD, 2023, 142

← 1 2 3 4 5 →