A High Dynamic Range Ion Detector for Multireflection Time-of-Flight Analyzers

被引：0

作者：

Stewart, Hamish ^{[1
]}

Petzoldt, Johannes ^{[1
]}

Shanley, Toby ^{[1
]}

Grinfeld, Dmitry ^{[1
]}

Denisov, Eduard ^{[1
]}

Hagedorn, Bernd ^{[1
]}

Dwivedi, Ankit ^{[1
]}

Mourad, Daniel ^{[1
]}

Ostermann, Robert ^{[1
]}

Ochmann, Maximilian ^{[1
]}

Cochems, Philipp ^{[1
]}

Wagner, Alexander ^{[1
]}

Balschun, Wilko ^{[1
]}

Makarov, Alexander ^{[1
]}

Shofman, Semyon ^{[2
]}

Moti, Ben-David ^{[2
]}

Weingarten, Amit ^{[2
]}

Kadyshevitch, Sasha ^{[2
]}

Hock, Christian ^{[1
]}

机构：

[1] Thermo Fisher Sci, D-28199 Bremen, Germany

[2] El Mul Technol Ltd, IL-7670315 Rehovot, Israel

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2024年 / 35卷 / 10期

关键词：

MASS ANALYZER;

D O I：

10.1021/jasms.4c00230

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Reflectron-based time-of-flight analyzers rely on subnanosecond detector time response to achieve acceptable resolving power for low-mid-mass, multiple-ion peaks. With the adoption of multireflection analyzers, order of magnitude longer folded ion paths relax restrictions on detector response time, allowing implementation of new technologies that greatly improve dynamic range, detector lifetime, and ion detection efficiency. A detection system is presented, integrated into a multireflection analyzer, that combines 10 keV postacceleration and focal plane correction with a unique BxE focusing, optically coupled detector, preamplification, and dual-channel digitization. Calibration and peak-handling methods are also described. The instrument demonstrated >1 x 10(4) dynamic range in a single shot, > 100k resolving power, and a relative immunity to detector aging.

引用

页码：2390 / 2399

页数：10

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