Diet/photoperiod mediated changes in cerebellar clock genes causes locomotor shifts and imperative changes in BDNF-TrkB pathway

被引：0

作者：

Karnik, Rhydham ^{[1
,2
]}

Vohra, Aliasgar ^{[1
,3
]}

Khatri, Mahamadtezib ^{[1
]}

Dalvi, Nilay ^{[1
]}

Vyas, Hitarthi S. ^{[1
,4
]}

Shah, Helly ^{[1
,2
]}

Gohil, Sujitsinh ^{[1
]}

Kanojiya, Smit ^{[1
,2
]}

Devkar, Ranjitsinh ^{[1
,2
]}

机构：

[1] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Zool, Div Chronobiol & Metab Endocrinol, Baroda, India

[2] Maharaja Sayajirao Univ Baroda, Dr Vikram Sarabhai Inst Cell & Mol Biol, Fac Sci, Baroda, India

[3] Washington Univ, Dept Neurol, St Louis, MO 63110 USA

[4] Univ Michigan, Dept Internal Med, Ann Arbor, MI USA

来源：

NEUROSCIENCE LETTERS | 2024年 / 835卷

关键词：

Locomotor deficits; Chronodisruption; Lifestyle Disorder; Neurobehavior; Bdnf-Trkb pathway; High fat diet; FATTY-ACIDS; DEPRESSION; MELATONIN; OSCILLATIONS; PLASTICITY; MICROGLIA;

D O I：

10.1016/j.neulet.2024.137843

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropsychological studies report anxiety and depression like symptoms in patients suffering from lifestyle disorder but its impact on locomotor function lacks clarity. Our study investigates locomotor deficits resulting due to perturbations in cerebellum of high fat diet (HFD), chronodisruption (CD) or a combination (HCD) model of lifestyle disorder. Significant downregulation in levels of cerebellar clock genes (Bmal-1, Clock, Per 1 and Per 2) and Bdnf-Trkb pathway genes (Bdnf, TrkB and Syn1 levels) were recorded. Further, locomotor deficits were observed in all the three experimental groups as evidenced by actimeter test, pole test and wire hanging test. Nuclear pyknosis of Purkinje cells, their derangement and inflammation were the hallmark of cerebellar tissue of all the three experimental groups. Taken together, this study generates important links between cerebellar clock oscillations, locomotor function and Bdnf-TrkB signaling.

引用

页数：7