Follicle-Stimulating Hormone Exacerbates Cardiovascular Disease in the Presence of Low or Castrate Testosterone Levels

被引：6

作者：

Duivenvoorden, Wilhelmina C. M. ^{[1
,2
]}

Margel, David ^{[3
,4
]}

Gayathri, Vishal Subramony ^{[2
]}

Duceppe, Emmanuelle ^{[5
,6
,7
]}

Yousef, Sadiya ^{[2
]}

Naeim, Magda ^{[2
]}

Khajehei, Mohammad ^{[1
]}

Hopmans, Sarah ^{[1
]}

Popovic, Snezana ^{[8
]}

Ber, Yaara ^{[3
]}

Heels-Ansdell, Diane ^{[9
]}

Devereaux, Philip J. ^{[5
,6
,7
]}

Pinthus, Jehonathan H. ^{[1
,2
,10
]}

机构：

[1] McMaster Univ, Fac Med, Dept Surg, Div Urol, Hamilton, ON, Canada

[2] Res Inst St Joes Hamilton, Hamilton, ON, Canada

[3] Rabin Med Ctr, Dept Urol, Petah Tiqwa, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[5] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada

[6] Hamilton Hlth Sci, Hamilton, ON, Canada

[7] Ctr Hosp Univ Montreal, Dept Med, Montreal, PQ, Canada

[8] McMaster Univ, Fac Med, Dept Pathol & Mol Med, Hamilton, ON, Canada

[9] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[10] McMaster Univ, Dept Surg Oncol Urooncol, 699 Concess St, Hamilton, ON L8V 5C2, Canada

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2024年 / 9卷 / 03期

关键词：

androgen-deprivation therapy; cardiovascular disease; follicle- stimulating hormone; GnRH-antagonist; prostate cancer; ANDROGEN-DEPRIVATION THERAPY; MYOCARDIAL INJURY; HOMEOSTATIC CHEMOKINES; NONCARDIAC SURGERY; 30-DAY MORTALITY; PROSTATE-CANCER; TROPONIN LEVELS; ATHEROSCLEROSIS; RISK; MEN;

D O I：

10.1016/j.jacbts.2023.10.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low testosterone (T), common in aging men, associates with cardiovascular disease. We investigated whether follicle -stimulating hormone (FSH), which is affected by T, modulates the cardiovascular effects associated with low T or castration. FSH b -/- :low-density lipoprotein receptor (LDLR) -/- mice, untreated or castrated (orchiectomy, gonadotropin-releasing hormone agonist or antagonist), demonstrated signi ficantly less atherogenesis compared with similarly treated LDLR -/- mice, but not following FSH delivery. Smaller plaque burden in LDLR -/- mice receiving gonadotropin-releasing hormone antagonists vs agonists were nulli fied in FSH b -/- :LDLR -/- mice. Atherosclerotic and necrotic plaque size and macrophage in filtration correlated with serum FSH/T. In patients with prostate cancer, FSH/T following androgen -deprivation therapy initiation predicted cardiovascular events. FSH facilitates cardiovascular disease when T is low or eliminated. (J Am Coll Cardiol Basic Trans Science 2024;9:364 -379) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：364 / 379

页数：16

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