Multivariate sharp-wave ripples in schizophrenia during awake state

被引:1
|
作者
Ohki, Takefumi [1 ,2 ]
Chao, Zenas C. [1 ]
Takei, Yuichi [2 ]
Kato, Yutaka [2 ,3 ]
Sunaga, Masakazu [2 ]
Suto, Tomohiro [4 ]
Tagawa, Minami [2 ,4 ]
Fukuda, Masato [2 ]
机构
[1] Univ Tokyo, Univ Tokyo Inst Adv Study UTIAS, Int Res Ctr Neurointelligence WPI IRCN, Tokyo, Japan
[2] Gunma Univ, Grad Sch Med, Dept Psychiat & Neurosci, Maebashi, Japan
[3] Tsutsuji Mental Hosp, Tatebayashi, Japan
[4] Gunma Prefectural Psychiat Med Ctr, Isesaki, Japan
基金
日本学术振兴会;
关键词
energy landscape analysis; generalized eigendecomposition; neural oscillations; phase-amplitude coupling; spontaneous activity; BLIND SOURCE SEPARATION; HIPPOCAMPAL; OSCILLATIONS; MEMORY; SYNCHRONY; SLEEP; NEOCORTEX; GLUTAMATE; DOPAMINE; SPINDLES;
D O I
10.1111/pcn.13702
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
AimsSchizophrenia (SZ) is a brain disorder characterized by psychotic symptoms and cognitive dysfunction. Recently, irregularities in sharp-wave ripples (SPW-Rs) have been reported in SZ. As SPW-Rs play a critical role in memory, their irregularities can cause psychotic symptoms and cognitive dysfunction in patients with SZ. In this study, we investigated the SPW-Rs in human SZ.MethodsWe measured whole-brain activity using magnetoencephalography (MEG) in patients with SZ (n = 20) and sex- and age-matched healthy participants (n = 20) during open-eye rest. We identified SPW-Rs and analyzed their occurrence and time-frequency traits. Furthermore, we developed a novel multivariate analysis method, termed "ripple-gedMEG" to extract the global features of SPW-Rs. We also examined the association between SPW-Rs and brain state transitions. The outcomes of these analyses were modeled to predict the positive and negative syndrome scale (PANSS) scores of SZ.ResultsWe found that SPW-Rs in the SZ (1) occurred more frequently, (2) the delay of the coupling phase (3) appeared in different brain areas, (4) consisted of a less organized spatiotemporal pattern, and (5) were less involved in brain state transitions. Finally, some of the neural features associated with the SPW-Rs were found to be PANSS-positive, a pathological indicator of SZ. These results suggest that widespread but disorganized SPW-Rs underlies the symptoms of SZ.ConclusionWe identified irregularities in SPW-Rs in SZ and confirmed that their alternations were strongly associated with SZ neuropathology. These results suggest a new direction for human SZ research.
引用
收藏
页码:507 / 516
页数:10
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