Green synthesis of quercetin-loaded magneto-liposomes and their assessment of antioxidant efficacy, hyperthermia and MRI contrast features

被引：2

作者：

Poornima, G. ^{[1
]}

Gupta, Somlee ^{[2
]}

Dhayalan, Arunkumar ^{[2
]}

Lahiri, B. B. ^{[3
,4
]}

Philip, John ^{[3
,4
]}

Kannan, S. ^{[1
]}

机构：

[1] Pondicherry Univ, Ctr Nanosci & Technol, Pondicherry 605014, India

[2] Pondicherry Univ, Dept Biotechnol, Pondicherry 605014, India

[3] Indira Gandhi Ctr Atom Res, Smart Mat Sect, Mat Characterizat Grp, Met & Mat Grp, Kalpakkam 603102, Tamil Nadu, India

[4] Homi Bhabha Natl Inst, Training Sch Complex, Mumbai 400094, India

来源：

MATERIALS CHEMISTRY AND PHYSICS | 2024年 / 323卷

关键词：

Fe3O4; nanoparticles; Quercetin; Magneto-liposomes; ROS scavenging; Anti-cancer; HEATING EFFICIENCY; RELEASE; FE3O4; OXIDE; NANOPARTICLES; DOXORUBICIN;

D O I：

10.1016/j.matchemphys.2024.129663

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Recent years has drawn attention in the preparation of precise theragnostic agents to treat various types of cancers. The current study describes the green synthesis of quercetin encapsulated magneto-liposomes and their subsequent evaluation of anti-cancer efficacy. Punica granatum L peel extract as a stabilizer has been used for the synthesis of Fe3O4 nanoparticles and the resultant exhibited a magnetic susceptibility of 51 emu/g. Quercetin encapsulated magneto-liposomes obtained via thin film hydration technique displayed a spherical size similar to 100 nm. DPPH and TBARS assays used for the assessment of quercetin antioxidant behaviour revealed a concentration-dependent upsurge in scavenging activity and a concurrent reduction in lipid peroxidation. Magnetic hyperthermia studies revealed superior heating efficiency (similar to 57.2 +/- 3.8 W/g(Fe)) of the magneto-liposomes under a biologically safe exposure condition of the oscillating magnetic field. The magnetic properties of Fe3O4 nanoparticles have been comprehensively examined through hyperthermia and in vitro magnetic resonance imaging (MRI) studies. In vitro studies performed in MG-63 osteosarcoma cells indicated the reduced viability of cancer cells similar to 45 % by the quercetin encapsulated magneto-liposomes. These nanocarriers also exhibited a very minimal cytotoxicity on non-cancerous HEK-293 cells. The results from the overall investigation unveiled the potential of quercetin encapsulated magneto-liposomes in cancer theranosis.

引用

页数：13