Rapid On-Site Screening of Six Kinds of Pesticide Residues in Cosmetics Containing Plant Extracts by Fan-shaped Paper Spray Ionization and Miniature Mass Spectrometry

Cosmetics containing plant extracts may pose health risks to consumers due to inadequate control over the quality of plant raw materials, which may lead to residues of pesticides such as carbendazim in cosmetics. Developing rapid detection methods is of paramount importance for regulating product quality and safeguarding human health. A rapid on -site analytical method was developed for the screening of six kinds of pesticide residues in plant extract -based cosmetics using fan -shaped paper spray ionization with chromatographic enrichment functionality coupled with a miniature mass spectrometer. Cosmetic samples were directly loaded onto the fanshaped paper substrate drop by drop, followed by chromatographic enrichment, paper spray ionization, and the miniature mass spectrometry analysis. The entire analysis time for a single run was less than 1 min. By loading samples in a dropwise manner, significantly improved chromatographic enrichment on the tip and 6 to 32 -fold signal enhancement were achieved on the fan -shaped paper substrate compared to traditional triangle -shaped paper substrate. The limits of detection (LODs) and quantitation (LOQs) for the six kinds of pesticides were 0.02-0.05 mg/kg and 0.05-0.10 mg/kg, respectively. The recoveries were 82.6%-101.8% with relative standard deviations of 8.3%-16.5%. The established method was convenient, sensitive, and suitable for rapid, on -site screening of pesticide residues in plant extract -based cosmetics.