A potent FGFR4-targeted antibody-drug conjugate therapy for patients with rhabdomyosarcoma and other cancers expressing FGFR4

被引:0
|
作者
Tian, Meijie
Jia, Katrina
Wu, Jerry T.
Wei, Jun S.
Cheuk, Adam T.
Zhang, Zhongmei
Pope, Eleanor G.
Shor, Boris
Tumey, L. Nathan
Khan, Javed
机构
关键词
D O I
10.1158/1538-7445.AM2024-LB042
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LB042
引用
收藏
页数:3
相关论文
共 50 条
  • [1] In vitro and in vivo activity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate
    Meyer, Matthew J.
    Jenkins, David
    Batt, David
    Mosher, Rebecca
    Isaacs, Randi
    Hu, Tiancen
    Capka, Vladimir
    Zhang, Xiamei
    Chen, Dongshu
    Tang, Lujia
    Daley, Mike
    Nowakowski, Patrycja
    Shim, Yeonju
    Jiang, Wei
    Ettenberg, Seth
    Lees, Emma
    CANCER RESEARCH, 2015, 75
  • [2] Potent tumoricidal activity of a FGFR4 CART in rhabdomyosarcoma.
    Cheuk, Adam
    Tian, Meijie
    Kumar, Jeetendra
    Azorsa, Peter
    Shivaprasad, Nityashree
    Schneider, Dina
    Gryder, Berkley
    Wei, Jun
    Song, Young
    Wen, Xinyu
    Sindiri, Sivasish
    Chung, Joon-Yong
    Zhu, Zhongyu
    Dimitrov, Dimiter
    Hewitt, Stephen
    Dropulic, Boro
    Orentas, Rimas
    Khan, Javed
    CANCER RESEARCH, 2021, 81 (13)
  • [3] Antibody-based targeting of the cell surface receptor tyrosine kinase FGFR4 in rhabdomyosarcoma and other cancers
    Skarzynski, Martin
    Shivaprasad, Nitya
    Subramanian, Baskar
    Azorsa, David
    Zhu, Zhongyu
    Dimitrov, Dimiter
    Khan, Javed
    CANCER RESEARCH, 2017, 77
  • [4] Anti-FGFR4 antibody drug conjugate for immune therapy of rhabdomyosarcoma and hepatocellular carcinoma
    Cheuk, Adam
    Shivaprasad, Nitya
    Skarzynski, Martin
    Baskar, Sivasubramanian
    Azorsa, Peter
    Khan, Javed
    CANCER RESEARCH, 2018, 78 (13)
  • [5] Development of FGFR4-targeted chimeric antigen receptors (CARs) for the treatment of rhabdomyosarcoma.
    Sullivan, Peter
    Kumar, Rajesh
    Li, Wei
    Wang, Lingyang
    Zhang, Yue
    Cheuk, Adam
    Shivaprasad, Nityashree
    Khan, Javed
    Dimitrov, Dimiter S.
    Orentas, Rimas J.
    CANCER RESEARCH, 2021, 81 (13)
  • [6] Potent antitumor activity of a FGFR4 CAR-T in rhabdomyosarcoma.
    Cheuk, Adam Tai Chi
    Tian, Meijie
    Shivaprasad, Nityashree
    Highfill, Steven
    Milewski, David
    Brown, G. Tom
    Azorsa, Peter
    Schneider, Dina
    Gryder, Berkley
    Wei, Jun S.
    Song, Young Kwok
    Chou, Hsien-Chao
    Wu, Jerry
    Chung, Joon-Yong
    Belyea, Brian
    Linardic, Corinne
    Hewitt, Stephen M.
    Dropulic, Boro
    Orentas, Rimas
    Khan, Javed
    CANCER RESEARCH, 2022, 82 (12)
  • [7] Identification of resistance mechanisms to FGFR4 targeted therapy in hepatocellular carcinoma
    Hatlen, Megan A.
    Schmidt-Kittler, Oleg
    Sherwin, Cori-Ann
    Rozsahegyi, Emily
    Rubin, Nooreen
    Sheets, Michael
    Kim, Joseph L.
    Miduturu, Chandra
    Bifulco, Neil
    Brooijmans, Natasja
    Shi, Hongliang
    Guzi, Timothy
    Boral, Andy
    Lengauer, Christoph
    Dorsch, Marion
    Kim, Richard D.
    Kang, Yoon-Koo
    Wolf, Beni B.
    Hoeflich, Klaus P.
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [8] Combination FGFR4 and ER-targeted therapy for invasive lobular carcinoma
    Levine, Kevin M.
    Chen, Jian
    Sikora, Matthew J.
    Tasdemir, Nilgun
    Priedigkeit, Nolan
    Tseng, George C.
    Puhalla, Shannon L.
    Jankowitz, Rachel C.
    Dabbs, David J.
    McAuliffe, Priscilla F.
    Lee, Adrian V.
    Oesterreich, Steffi
    CANCER RESEARCH, 2018, 78 (04)
  • [9] Combination FGFR4 and ER-targeted therapy for invasive lobular carcinoma
    Levine, Kevin
    Chen, Jian
    Sikora, Matthew
    Tasdemir, Nilgun
    Tseng, George
    Puhalla, Shannon
    Jankowitz, Rachel
    Dabbs, David
    McAuliffe, Priscilla
    Lee, Adrian
    Oesterreich, Steffi
    CANCER RESEARCH, 2017, 77
  • [10] FGFR4 specific chimeric antigen receptor (CAR) T cell therapy against rhabdomyosarcoma
    Shivaprasad, Nityashree
    Yohe, Marielle
    Xiong, Ying
    Wu, Darong
    Azorsa, Peter
    Cheuck, Adam
    Chung, Joon-Yong
    Zhu, Zhongyu
    Dimitrov, Dimiter
    Hewitt, Stephen
    Dropulic, Boro
    Schneider, Dina
    Orentas, Rimas
    Khan, Javed
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5