Dissemination of extensively drug-resistant NDMproducing Providencia stuartii in Europe linked to patients transferred from Ukraine, March 2022 to March 2023

被引：6

作者：

Witteveen, Sandra ^{[1
]}

Hans, Joerg B. ^{[2
,3
]}

Izdebski, Radoslaw ^{[4
]}

Hasman, Henrik ^{[5
]}

Samuelsen, Orjan ^{[6
,7
]}

Dortet, Laurent ^{[8
]}

Pfeifer, Yvonne ^{[9
]}

Delappe, Niall ^{[10
]}

Oteo-Iglesias, Jesus ^{[11
,12
]}

Zabicka, Dorota ^{[13
]}

Cormican, Martin ^{[10
]}

Sandfort, Mirco ^{[3
]}

Reichert, Felix ^{[3
]}

Poentinen, Anna K. ^{[6
,14
]}

Fischer, Martin A. ^{[9
]}

Verkaik, Nelianne ^{[15
]}

Perez-Vazquez, Maria ^{[11
,12
]}

Pfennigwerth, Niels ^{[2
]}

Hammerum, Anette M. ^{[5
]}

Hallstrom, Soren ^{[5
]}

Biedrzycka, Marta ^{[4
]}

Raeisaenen, Kati ^{[16
]}

Wielders, Cornelia C. H. ^{[1
]}

Urbanowicz, Pawel ^{[4
]}

de Haan, Angela ^{[1
]}

Westmo, Karin ^{[17
]}

Landman, Fabian ^{[1
]}

van der Heide, Han G. J. ^{[1
]}

Lansu, Simon ^{[1
]}

Zwittink, Romy ^{[1
]}

Notermans, Daan W. ^{[1
]}

Guzek, Aneta ^{[18
]}

Kondratiuk, Viacheslav ^{[19
]}

Salmanov, Aidyn ^{[20
]}

Haller, Sebastian ^{[3
]}

Linkevicius, Marius ^{[21
]}

Gatermann, Soeren ^{[2
]}

Kohlenberg, Anke ^{[21
]}

Gniadkowski, Marek ^{[4
]}

Werner, Guido ^{[9
]}

Hendrickx, Antoni P. A. ^{[1
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, Ctr Infect Dis Control CIb, Bilthoven, Netherlands

[2] Ruhr Univ Bochum, German Natl Reference Ctr Multidrug Resistant Gram, Dept Med Microbiol, Bochum, Germany

[3] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany

[4] Natl Med Inst, Dept Mol Microbiol, Warsaw, Poland

[5] Statens Serum Inst, Dept Bacteria Parasites & Fungi, Natl Reference Lab Antimicrobial Resistance, Copenhagen, Denmark

[6] Univ Hosp North Norway, Dept Microbiol & Infect Control, Norwegian Natl Advisory Unit Detect Antimicrobial, Tromso, Norway

[7] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Pharm, Tromso, Norway

[8] Paris Saclay Univ, Bicetre Hosp, AP HP, French Natl Reference Ctr Antimicrobial Resistance, Paris, France

[9] Robert Koch Inst, Dept Infect Dis, Div Nosocomial Pathogens & Antibiot Resistances, Wernigerode Branch, Wernigerode, Germany

[10] Univ Galway, Galway, Ireland

[11] Inst Salud Carlos III, Reference & Res Lab Antibiot Resistance, Natl Ctr Microbiol, Madrid, Spain

[12] Inst Salud Carlos III, CIBERINFEC, Madrid, Spain

[13] Natl Med Inst, Dept Epidemiol & Clin Microbiol, Warsaw, Poland

[14] Univ Oslo, Fac Med, Dept Biostat, Oslo, Norway

[15] Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

[16] Finnish Inst Hlth & Welf, Dept Hlth Secur, Helsinki, Finland

[17] Publ Hlth Agcy Sweden, Dept Microbiol, Solna, Sweden

[18] Natl Res Inst, Mil Inst Med, Dept Lab Diagnost, Sect Microbiol, Warsaw, Poland

[19] Natl Pirogov Mem Univ, Vinnytsia, Ukraine

[20] Shupyk Natl Healthcare Univ Ukraine, Kiev, Ukraine

[21] European Ctr Dis Prevent & Control ECDC, Stockholm, Sweden

来源：

EUROSURVEILLANCE | 2024年 / 29卷 / 23期

关键词：

OUTBREAK;

D O I：

10.2807/1560-7917.ES.2024.29.23.2300616

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: The war in Ukraine led to migration of Ukrainian people. Early 2022, several European national surveillance systems detected multidrugresistant (MDR) bacteria related to Ukrainian patients. Aim: To investigate the genomic epidemiology of New Delhi metallo-beta-lactamase (NDM)-producing Providencia stuartii from Ukrainian patients among European countries. Methods: Whole-genome sequencing of 66 isolates sampled in 2022-2023 in 10 European countries enabled whole-genome multilocus sequence typing (wgMLST), identification of resistance genes, replicons, and plasmid reconstructions. Five blaNDM-1-car- rying-P. stuartii isolates underwent antimicrobial susceptibility testing (AST). Transferability to Escherichia coli of a blaNDM-1-carrying plasmid from a patient strain was assessed. Epidemiological characteristics of patients with NDM-producing P. stuartii were gathered by questionnaire. Results: wgMLST of the 66 isolates revealed two genetic clusters unrelated to Ukraine and three linked to Ukrainian patients. Of these three, two comprised blaNDM-1-carry- ing-P. stuartii and the third blaNDM-5-carrying-P. stuartii. The blaNDM-1 clusters (PstCluster-001, n = 22 isolates; PstCluster-002, n = 8 isolates) comprised strains from seven and four countries, respectively. The blaNDM-5 cluster (PstCluster-003) included 13 isolates from six countries. PstCluster-001 and PstCluster-002 isolates carried an MDR plasmid harbouring blaNDM-1,blaOXA-10, blaCMY-16, rmtC and armA, which was transferrable in vitro and, for some Ukrainian patients, shared by other Enterobacterales. AST revealed PstCluster-001 isolates to be extensively drug -resistant (XDR), but susceptible to cefiderocol and aztreonam-avibactam. Patients with data on age (n = 41) were 19-74 years old; of 49 with information on sex, 38 were male. Conclusion: XDR P. stuartii were introduced into European countries, requiring increased awareness and precautions when treating patients from conflict -affected areas.

引用

页数：13

共 4 条

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