Rh(<sc>iii</sc>)-catalyzed regioselective C(sp2)-H alkenylation of isoquinolones with methoxyallene: A facile access to aldehyde-bearing isoquinolones

被引：1
|
作者：
Thakur, Ankita [1 ,2 ]
Chandra, Devesh [1 ]
Sharma, Upendra [1 ,2 ]
机构：
[1] CSIR IHBT, Chem Technol Div, C H Activat & Phytochemistry Lab, Palampur 176061, Himachal Prades, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 32期
关键词：
C-H ACTIVATION; ALLENES; FUNCTIONALIZATIONS; ALKOXYALLENES; ALLYLATION; REACTIVITY; ARENES;
D O I：
10.1039/d4ob01084a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and rapid access to isoquinolone aldehyde scaffolds has been established by a rhodium-catalyzed reaction between isoquinolone and methoxyallene that forges alkenylation in an explicit regioselective manner. Herein, methoxyallene serving as an acrolein equivalent results in execution of this unique functionalization. Furthermore, the compatibility with complex molecules underscores the significance of this developed protocol. The mechanistic proposal for this regioselective transformation was consistent with kinetic studies and several control reactions.
引用
收藏
页码：6612 / 6616
页数：5
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