Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses

被引：2
|
作者：
Cai, Qiang [1 ]
Tian, Yihao [2 ]
Shubhra, Quazi T. H. [1 ,3 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Neurosurg, Wuhan 430060, Peoples R China
[2] Wuhan Univ, Sch Basic Med Sci, Dept Human Anat Histol & Embryol, Wuhan, Peoples R China
[3] Univ Silesia Katowice, Inst Chem, Szkolna 9, PL-40006 Katowice, Poland
来源：
CELL METABOLISM | 2024年 / 36卷 / 05期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.cmet.2024.04.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrientscarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase's crucial role in regulating lipid metabolism in CD8 + T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.
引用
收藏
页码：884 / 886
页数：3
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