Rewiring CD8+T cell responses to PD-1 immune checkpoint blockade in PDAC by preventing terminal exhaustion via the inhibitory receptor PSGL-1

被引：0
|
作者：
Hope, Jennifer L.
Zhang, Yijuan
Hetrick, Hannah A.
Romano, Gabriele
Roy, Sreeja
Lin, Michelle
Palete, Ashley B.
Maganti, Swetha
Otero, Dennis C.
Commisso, Cosimo
Bradley, Linda M.
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-1359
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1359
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Rewiring CD8+ T cell responses to PD-1 immune checkpoint blockade in PDAC via the inhibitory receptor PSGL-1
    Hope, Jennifer L.
    Zhang, Yijuan
    Hetrick, Hannah A. F.
    Hernandez, Evelyn S. Sanchez
    Romano, Gabriele
    Roy, Sreeja
    Lin, Michelle
    Palete, Ashley B.
    Maganti, Swetha
    Otero, Dennis C.
    Byrne, Katelyn T.
    Commisso, Cosimo
    Bradley, Linda M.
    CANCER RESEARCH, 2024, 84 (17)
  • [2] PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion
    Tinoco, Roberto
    Carrette, Florent
    Barraza, Monique L.
    Otero, Dennis C.
    Magana, Jonathan
    Bosenberg, Marcus W.
    Swain, Susan L.
    Bradley, Linda M.
    IMMUNITY, 2016, 44 (05) : 1190 - 1203
  • [3] PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells
    Viramontes, Karla M.
    Neubert, Emily N.
    DeRogatis, Julia M.
    Tinoco, Roberto
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [4] PSGL-1 attenuates early TCR signaling to suppress CD8+T cell progenitor differentiation and elicit terminal CD8+T cell exhaustion
    Hope, Jennifer L.
    Otero, Dennis C.
    Bae, Eun-Ah
    Stairiker, Christopher J.
    Palete, Ashley B.
    Faso, Hannah A.
    Lin, Michelle
    Henriquez, Monique L.
    Roy, Sreeja
    Seo, Hyungseok
    Lei, Xue
    Wang, Eric S.
    Chow, Savio
    Tinoco, Roberto
    Daniels, Gregory A.
    Yip, Kevin
    Campos, Alexandre Rosa
    Yin, Jun
    Adams, Peter D.
    Rao, Anjana
    Bradley, Linda M.
    CELL REPORTS, 2023, 42 (05):
  • [5] PD-1 immune checkpoint blockade can synergize with PSGL-1 inhibition to reinvigorate exhausted T cells
    Viramontes, Karla M.
    Neubert, Emily N.
    DeRogatis, Julia M.
    Henriquez, Monique
    Tinoco, Roberto
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [6] Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma
    Pereira, Joao L.
    Arede, Liliana
    Ferreira, Francisca
    Matos, Andreia
    Pereira, Dulcineia
    Santos, Rita F.
    Carmo, Alexandre M.
    Oliveira, Maria J.
    Machado, Jose C.
    Duarte, Delfim
    dos Santos, Nuno R.
    LEUKEMIA, 2025, 39 (01) : 178 - 188
  • [7] PSGL-1, an immune checkpoint regulator that promotes T cell exhaustion in chronic viral infection and cancer
    Tinoco, Roberto
    Carrette, Florent
    Barraza, Monique
    Magana, Jonathan
    Swain, Susan
    Bradley, Linda
    JOURNAL OF IMMUNOLOGY, 2015, 194
  • [8] PSGL-1 Immune Checkpoint Inhibition for CD4+ T Cell Cancer Immunotherapy
    DeRogatis, Julia M.
    Viramontes, Karla M.
    Neubert, Emily N.
    Tinoco, Roberto
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [9] PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion (vol 44, pg 1190, 2016)
    Tinoco, Roberto
    Carrette, Florent
    Barraza, Monique L.
    Otero, Dennis C.
    Magana, Jonathan
    Bosenberg, Marcus W.
    Swain, Susan L.
    Bradley, Linda M.
    IMMUNITY, 2016, 44 (06) : 1470 - 1470
  • [10] Contrasting roles of PSGL-1 and PD-1 in regulating T-cell exhaustion and function during chronic viral infection
    Viramontes, Karla M.
    Thone, Melissa N.
    de la Torre, Jamie-Jean
    Neubert, Emily N.
    Derogatis, Julia M.
    Garcia, Chris
    Henriquez, Monique L.
    Tinoco, Roberto
    JOURNAL OF VIROLOGY, 2025, 99 (03)
12345