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A global perspective on the status of clinical metabolomics in laboratory medicine - a survey by the IFCC metabolomics working group
被引:1
|作者:
Fux, Elie
[1
]
Lenski, Marie
[2
,3
]
Bendt, Anne K.
[4
]
Otvos, James D.
[5
]
Ivanisevic, Julijana
[6
]
De Bruyne, Sander
[7
]
Cavalier, Etienne
[8
]
Friedecky, David
[9
,10
]
机构:
[1] Roche Diagnost GmbH, Nonnenwald 2, Penzberg, Germany
[2] Univ Lille, IMPECS IMPact Environm Chim Sante Humaine, CHU Lille, Inst Pasteur Lille,ULR 4483, F-59000 Lille, France
[3] CHU Lille, Unite Fonct Toxicol, Lille, France
[4] Natl Univ Singapore, Life Sci Inst, Singapore Lipid Incubator, Singapore, Singapore
[5] NHLBI, NIH, Translat Vasc Med Branch, Lipoprot Metab Lab, Bethesda, MD USA
[6] Univ Lausanne, Fac Biol & Med, Metabol Unit, Lausanne, Switzerland
[7] Ghent Univ Hosp, Dept Lab Med, Ghent, Belgium
[8] Univ Liege, CHU Liege, Dept Clin Chem, CIRM, Liege, Belgium
[9] Univ Hosp Olomouc, Dept Clin Biochem, Zdravotniku 7, Olomouc 77900, Czech Republic
[10] Palacky Univ Olomouc, Fac Med & Dent, Olomouc, Czech Republic
关键词:
clinical metabolomics;
clinical lipidomics;
emerging technologies;
diagnostics;
prognostics;
laboratory medicine;
CORONARY-ARTERY-DISEASE;
CERAMIDES;
TOOL;
D O I:
10.1515/cclm-2024-0550
中图分类号:
R446 [实验室诊断];
R-33 [实验医学、医学实验];
学科分类号:
1001 ;
摘要:
Objectives: Metabolomics aims for comprehensive characterization and measurement of small molecule metabolites (<1700 Da) in complex biological matrices. This study sought to assess the current understanding and usage of metabolomics in laboratory medicine globally and evaluate the perception of its promise and future implementation. Methods: A survey was conducted by the IFCC metabolomics working group that queried 400 professionals from 79 countries. Participants provided insights into their experience levels, knowledge, and usage of metabolomics approaches, along with detailing the applications and methodologies employed. Results: Findings revealed a varying level of experience among respondents, with varying degrees of familiarity and utilization of metabolomics techniques. Targeted approaches dominated the field, particularly liquid chromatography coupled to a triple quadrupole mass spectrometer, with untargeted methods also receiving significant usage. Applications spanned clinical research, epidemiological studies, clinical diagnostics, patient monitoring, and prognostics across various medical domains, including metabolic diseases, endocrinology, oncology, cardiometabolic risk, neurodegeneration and clinical toxicology. Conclusions: Despite optimism for the future of clinical metabolomics, challenges such as technical complexity, standardization issues, and financial constraints remain significant hurdles. The study underscores the promising yet intricate landscape of metabolomics in clinical practice, emphasizing the need for continued efforts to overcome barriers and realize its full potential in patient care and precision medicine.
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页码:1950 / 1961
页数:12
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