Macrophage M2 polarization promotes pulpal inflammation resolution during orthodontic tooth movement

被引：2

作者：

Li, Jichang ^{[1
,2
,3
,4
]}

Ren, Huiying ^{[1
,2
,3
,4
]}

Zhang, Zijie ^{[1
,2
,3
,4
]}

Zhang, Jin ^{[2
,3
,5
,6
]}

Wei, Fulan ^{[1
,2
,3
,4
]}

机构：

[1] Shandong Univ, Hosp Stomatol, Cheeloo Coll Med, Sch, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China

[2] Shandong Key Lab Oral Tissue Regenerat, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China

[3] Shandong Engn Lab Dent Mat & Oral Tissue Regenerat, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China

[4] Shandong Prov Clin Res Ctr Oral Dis, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China

[5] Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Dept Endodont, Jinan, Shandong, Peoples R China

[6] Shandong Prov Clin Res Ctr Oral Dis, Jinan, Shandong, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2024年 / 28卷 / 09期

基金：

中央高校基本科研业务费专项资金资助;

关键词：

dental pulp; hypoxia; inflammation; macrophage polarization; mechanical force; orthodontic tooth movement; HUMAN DENTAL-PULP; HYPOXIA; ACTIVATION; INTRUSION; REPAIR; TISSUE;

D O I：

10.1111/jcmm.18350

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mechanical force induces hypoxia in the pulpal area by compressing the apical blood vessels of the pulp, triggering pulpal inflammation during orthodontic tooth movement. However, this inflammation tends to be restorable. Macrophages are recognized as pivotal immunoreactive cells in the dental pulp. Whether they are involved in the resolution of pulpal inflammation in orthodontic teeth remains unclear. In this study, we investigated macrophage polarization and its effects during orthodontic tooth movement. It was demonstrated that macrophages within the dental pulp polarized to M2 type and actively participated in the process of pulpal inflammation resolution. Inflammatory reactions were generated and vascularization occurred in the pulp during orthodontic tooth movement. Macrophages in orthodontic pulp show a tendency to polarize towards M2 type as a result of pulpal hypoxia. Furthermore, by blocking M2 polarization, we found that macrophage M2 polarization inhibits dental pulp-secreting inflammatory factors and enhances VEGF production. In conclusion, our findings suggest that macrophages promote pulpal inflammation resolution by enhancing M2 polarization and maintaining dental health during orthodontic tooth movement.

引用

页数：11