Research progress in Alzheimer's disease and bone-brain axis

被引：4
|
作者：
Zhang, Fan [1 ]
Zhang, Wei [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100070, Peoples R China
[2] Capital Med Univ, Beijing Tiantan Hosp, Ctr Cognit Neurol, Dept Neurol, Beijing 100070, Peoples R China
[3] Beijing Tiantan Hosp, 119 South Fourth Ring Rd West, Beijing, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2024年 / 98卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; Orthopedic diseases; Bone-brain axis; Research progress; MILD COGNITIVE IMPAIRMENT; EXTRACELLULAR VESICLES; RHEUMATOID-ARTHRITIS; OSTEOARTHRITIS; PATHOGENESIS; OSTEOPONTIN; ASSOCIATION; OSTEOCALCIN; DAMAGE; DKK1;
D O I：
10.1016/j.arr.2024.102341
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of epidemiology and pathogenesis. Brain and bone tissues can regulate each other in different manners through bone-brain axis. This article reviews the research progress of the relationship between AD and orthopedic diseases, bone-brain axis mechanisms of AD, and AD therapy by targeting bone-brain axis, in order to deepen the understanding of bone-brain communication, promote early diagnosis and explore new therapy for AD patients.
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收藏
页数：12
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