Correlation of severity & clinical outcomes of COVID-19 with virus variants: A prospective, multicentre hospital network study

被引：0

作者：

Wadhwa, Komal ^{[1
]}

Malik, Shilpa ^{[1
]}

Balaji, Srinigila ^{[1
]}

Thiruvengadam, Ramachandran ^{[2
]}

Bashyam, Murali Dharan ^{[8
]}

Bhattacharya, Prasanta Kumar ^{[12
]}

Behera, Bijayini ^{[13
]}

Bhardwaj, Pankaj ^{[16
]}

Biswas, Nidhan K. ^{[18
]}

Das, Asim ^{[7
]}

Dey, Anindya ^{[20
]}

Dhotre, Dhiraj ^{[22
]}

Dias, Mary ^{[22
]}

Dubey, Pankaj ^{[25
]}

Dutta, Shreelekha ^{[18
]}

Gadepalli, Ravisekhar ^{[17
]}

Gosain, Mudita ^{[2
]}

Goud, Kalal Iravaty ^{[10
]}

Gupta, Neeraj Kumar ^{[26
]}

Gupta, Nitesh ^{[26
]}

Jana, Pradipta ^{[3
]}

Jena, Deepak ^{[15
]}

John, Elizabeth ^{[24
]}

Karunanidhi, Arunkumar ^{[9
]}

Khan, S. Muhammad Salim ^{[29
]}

Khattar, Sahil ^{[4
]}

Paul, Abhilash Prabhakar Kundavaram ^{[31
]}

Kumar, Shakti ^{[3
]}

Maitra, Arindam ^{[18
]}

Modi, Nikhil ^{[27
]}

Moorthy, Mahesh ^{[32
]}

Nagaraj, Savitha ^{[23
]}

Palakodeti, Dasaradhi ^{[24
]}

Pandey, Anil Kumar ^{[5
]}

Pandey, Aparna ^{[6
]}

Raghav, Sunil Kumar ^{[15
]}

Ramasubban, Suresh ^{[19
]}

Raghavan, Sreevatsan ^{[2
]}

Harikrishnan, S. ^{[33
]}

Krishnamoorthy, S. ^{[35
]}

Selvamurugan, Selvaraj ^{[34
]}

Sardana, Raman ^{[28
]}

Shouche, Yogesh ^{[21
]}

Singh, Akanksha ^{[1
]}

Singh, Arvind Kumar ^{[14
]}

Ramasubramaniyan, V. ^{[36
]}

Yadav, Monika ^{[1
]}

Zahoor, Danish ^{[30
]}

Narreddy, Suneetha ^{[11
]}

Bhatnagar, Shinjini ^{[2
]}

机构：

[1] ESIC Med Coll & Hosp, Clin Dev Serv Agcy, Faridabad, Haryana, India

[2] ESIC Med Coll & Hosp, Ctr Maternal & Child Hlth, Faridabad, India

[3] ESIC Med Coll & Hosp, Infect & Immunol, Faridabad, India

[4] ESIC Med Coll & Hosp, Ctr Data Management, Faridabad, India

[5] ESIC Med Coll & Hosp, Faridabad, Haryana, India

[6] ESIC Med Coll & Hosp, Dept Microbiol, Faridabad, Haryana, India

[7] ESIC Med Coll & Hosp, Faridabad, Haryana, India

[8] Apollo Hosp, Lab Mol Oncol, Telangana, Hyderabad, Pakistan

[9] Apollo Hosp, Ctr DNA Fingerprinting & Diagnost, Hyderabad, Telangana, Pakistan

[10] Apollo Hosp, Mol Biol & Cytogenet, Hyderabad, Telangana, Pakistan

[11] Apollo Hosp, Dept Infect Med, Telangana, Hyderabad, Pakistan

[12] North Eastern Indira Gandhi Reg Inst, Dept Gen Med, Shillong, Meghalaya, India

[13] All India Inst Med Sci, Dept Microbil, Bhubaneswar, Odisha, India

[14] All India Inst Med Sci, Community Med & Family Med, Bhubaneswar, Odisha, India

[15] Inst Life Sci, Immunogen & Syst Biol Lab, Bhubaneswar, Odisha, India

[16] All India Inst Med Sci, Dept Community Med & Family Med, Jodhpur, Rajasthan, India

[17] All India Inst Med Sci, Dept Microbiol, Jodhpur, Rajasthan, India

[18] Natl Inst Biomed Genom, Kalyani, India

[19] Apollo Hosp, Dept Crit care, Kolkata, West Bengal, India

[20] Apollo Hosp, Dept & Microbiol, Kolkata, West Bengal, India

[21] Natl Ctr Microbiol Resource, Pune, Maharashtra, India

[22] Natl Ctr Cell Sci, Pune, Maharashtra, India

[23] St Johns Med Coll & Hosp, Dept Microbiol, Bengaluru, Karnataka, India

[24] Inst Stem Cell Sci & Regenerat Med, Bengaluru, Karnataka, India

[25] Apollo Hosp, Dept Crit Care, Ahmadabad, Gujarat, India

[26] Vardhman Mahavir Med Coll, Dept Pulm Crit Care & Sleep Med, New Delhi, India

[27] Apollo Hosp, Dept Resp Crit Care & Sleep Med, New Delhi, India

[28] Apollo Hosp, Dept Microbiol, New Delhi, India

[29] Govt Med Coll, Dept Community Med, Srinagar, Jammu & Kashmir, India

[30] Govt Med Coll, Dept Microbiol, Srinagar, Jammu & Kashmir, India

[31] Christian Med Coll & Hosp, Emergency Dept, Vellore, India

[32] Christian Med Coll & Hosp, Dept Clin Virol, Vellore, India

[33] Apollo Hosp, Dept Pulmonol, Madurai, India

[34] Apollo Hosp, Dept Clin Res, Madurai, India

[35] Apollo Hosp, Dept Internal Med, Chennai, Tamil Nadu, India

[36] Apollo Hosp, Dept Infect Dis & Trop Med, Chennai, Tamil Nadu, India

来源：

INDIAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 159卷 / 01期

关键词：

COVID-19; Delta; Omicron; SARS-CoV-2; severity; variants of concern;

D O I：

10.4103/ijmr.ijmr_1041_23

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background & objectives:The clinical course of COVID-19 and its prognosis are influenced by both viral and host factors. The objectives of this study were to develop a nationwide platform to investigate the molecular epidemiology of SARS-CoV-2 (Severe acute respiratory syndrome Corona virus 2) and correlate the severity and clinical outcomes of COVID-19 with virus variants. Methods:A nationwide, longitudinal, prospective cohort study was conducted from September 2021 to December 2022 at 14 hospitals across the country that were linked to a viral sequencing laboratory under the Indian SARS-CoV-2 Genomics Consortium. All participants (18 yr and above) who attended the hospital with a suspicion of SARS-CoV-2 infection and tested positive by the reverse transcription-PCR method were included. The participant population consisted of both hospitalized as well as outpatients. Their clinical course and outcomes were studied prospectively. Nasopharyngeal samples collected were subjected to whole genome sequencing to detect SARS-CoV-2 variants. Results:Of the 4972 participants enrolled, 3397 provided samples for viral sequencing and 2723 samples were successfully sequenced. From this, the evolution of virus variants of concern including Omicron subvariants which emerged over time was observed and the same reported here. The mean age of the study participants was 41 yr and overall 49.3 per cent were female. The common symptoms were fever and cough and 32.5 per cent had comorbidities. Infection with the Delta variant evidently increased the risk of severe COVID-19 (adjusted odds ratio: 2.53, 95% confidence interval: 1.52, 4.2), while Omicron was milder independent of vaccination status. The independent risk factors for mortality were age >65 yr, presence of comorbidities and no vaccination. Interpretation & conclusions:The authors believe that this is a first-of-its-kind study in the country that provides real-time data of virus evolution from a pan-India network of hospitals closely linked to the genome sequencing laboratories. The severity of COVID-19 could be correlated with virus variants with Omicron being the milder variant.

引用

页码：91 / 101

页数：14

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