Targeted degradation of undruggable proteins using a novel heterobifunctional proteomimetic platform

被引：0
|
作者：
Wang, Max
Truica, Mihai
Gattis, Brayley
Zhang, Xiaoyu
Abdulkadir, Sarki
Gianneschi, Nathan
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-3882
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A3882
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Targeted degradation of undruggable proteins using a novel heterobifunctional proteomimetic platform.
    Wang, Max Mu
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (23_SUPPL) : 47 - 47
  • [2] Targeted protein degradation: A promise for undruggable proteins
    Samarasinghe, Kusal T. G.
    Crews, Craig M.
    CELL CHEMICAL BIOLOGY, 2021, 28 (07) : 934 - 951
  • [3] Development of heterobifunctional proteomimetic polymers for delivery of MYC inhibitory peptides and targeted MYC degradation.
    Truica, Mihai Ioan
    Wang, Max Mu
    Gattis, Brayley
    Abdulkadir, Sarki
    Gianneschi, Nathan
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [4] First-in-class heterobifunctional proteomimetic polymer capable of direct inhibition of Myc and target it for degradation
    Wang, M.
    Trucia, M.
    Gattis, B.
    Abdulkadir, S.
    Gianneschi, N.
    EUROPEAN JOURNAL OF CANCER, 2022, 174 : S36 - S37
  • [5] Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule
    Wigle, Tim J.
    Ren, Yue
    Molina, Jennifer R.
    Blackwell, Danielle J.
    Schenkel, Laurie B.
    Swinger, Kerren K.
    Kuplast-Barr, Kristy
    Majer, Christina R.
    Church, W. David
    Lu, Alvin Z.
    Mo, Jason
    Abo, Ryan
    Cheung, Anne
    Dorsey, Bryan W.
    Niepel, Mario
    Perl, Nicholas R.
    Vasbinder, Melissa M.
    Keilhack, Heike
    Kuntz, Kevin W.
    CHEMBIOCHEM, 2021, 22 (12) : 2107 - 2110
  • [6] Inducing the Degradation of Disease-Related Proteins Using Heterobifunctional Molecules
    Delport, Alexandre
    Hewer, Raymond
    MOLECULES, 2019, 24 (18):
  • [7] Targeted degradation of PARP14 Using a heterobifunctional small molecule.
    Wigle, Tim
    Ren, Yue
    Molina, Jennifer
    Blackwell, Danielle
    Schenkel, Laurie
    Swinger, Kerren
    Cheug, Anne
    Abo, Ryan
    Minissale, Elena
    Lu, Alvin
    Majer, Christina
    Church, William
    Dorsey, Bryan
    Niepel, Mario
    Perl, Nicholas
    Kuplast-Barr, Kristy
    McEachern, Kristen
    Vasbinder, Melissa
    Keilhack, Heike
    Kuntz, Kevin
    CANCER RESEARCH, 2021, 81 (13)
  • [8] Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders
    Gadiyar, Varsha
    Patel, Gopi
    Chen, Jesse
    Vigil, Dominico
    Ji, Nan
    Campbell, Veronica
    Sharma, Kirti
    Shi, Yatao
    Weiss, Matthew M.
    Birge, Raymond B.
    Davra, Viralkumar
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [9] Advancement of targeted protein degradation strategies as therapeutics for undruggable disease targets
    Kannan, Mayuri P.
    Sreeraman, Sarojini
    Somala, Chaitanya S.
    Kushwah, Raja B. S.
    Mani, Saravanan K.
    Sundaram, Vickram
    Thirunavukarasou, Anand
    FUTURE MEDICINAL CHEMISTRY, 2023, 15 (10) : 867 - 883
  • [10] Novartis, Berkeley sign drug chemistry pact Chemoproteomics and targeted protein degradation could hit previously undruggable proteins
    Cross, Ryan
    CHEMICAL & ENGINEERING NEWS, 2017, 95 (39) : 12 - 12
12345