Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors

被引：6

作者：

Taibi, Mohamed ^{[1
,2
]}

Elbouzidi, Amine ^{[1
,3
]}

Haddou, Mounir ^{[1
,2
]}

Belbachir, Yousra ^{[4
]}

Baraich, Abdellah ^{[5
]}

Khalil, Zineb ^{[6
]}

Bellaouchi, Reda ^{[5
]}

Asehraou, Abdeslam ^{[5
]}

Addi, Mohamed ^{[1
]}

AL-Farga, Ammar ^{[7
]}

Al-Maaqar, Saleh M. ^{[8
]}

El Guerrouj, Bouchra ^{[1
,2
]}

Chaabane, Khalid ^{[1
]}

机构：

[1] Univ Mohammed Premier, Fac Sci, Lab Ameliorat Prod Agr Biotechnol & Environm LAPAB, Oujda, Morocco

[2] Univ Mohammed Premier, Ctr Oriental Sci Technol Eau Environm COSTEE, Oujda, Morocco

[3] Euro Mediterranean Univ Fes UEMF, Fes, Morocco

[4] Mohammed First Univ, Fac Sci, Dept Chem, Lab Appl Chem & Environm LCAE, Oujda, Morocco

[5] Mohammed First Univ, Fac Sci, Lab Bioresources Biotechnol Ethnopharmacol & Hlth, Oujda, Morocco

[6] Inst Super Profess Infirmieres & Tech St Casablanc, Rue Mohamed Faidouzi Casablanca Maroc ZK, Casablanca, Morocco

[7] Univ Jeddah, Dept Biochem, Fac Sci, Jeddah, Saudi Arabia

[8] Albaydha Univ, Fac Educ, Dept Biol, POB 82883, Al Baydha, Yemen

来源：

CYTA-JOURNAL OF FOOD | 2024年 / 22卷 / 01期

关键词：

Clinopodium nepeta subsp. ascendens; essential oil; GC-MS; biological activities; cancer cell lines; food additive; health benefits; nutraceutical; ANTIINFLAMMATORY ACTIVITIES; PROLIFERATION; CELLS;

D O I：

10.1080/19476337.2024.2348735

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study delves into the biological characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco. Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochemical analysis via gas chromatography-mass spectrometry (GC-MS), revealing 21 terpene compounds, notably Dihydrocarvone (22.70%), Neoisomenthol (43.59%), and Pulegone (20.55%). These compounds, recognized for their biological and pharmacological attributes, were further investigated for their potential applications. Notably, CNEO exhibited dose-dependent anti-inflammatory effects by attenuating nitric oxide (NO) and prostaglandin E2 (PGE2) production. Moreover, it demonstrated promising anticancer activity against MDA-MB-468, HepG2, and HCT-15 cancer cell lines, rivaling doxorubicin's effectiveness. These findings underscore CNEO's nutraceutical potential, particularly in food science and industry, suggesting its use as a functional food additive with both nutritional and health benefits

引用

页数：9

共 19 条

[1] Exploring the Pharmacological Potential of the Chemically Characterized Essential Oil from Clinopodium nepeta subsp. ascendens: A Combined In Vitro and In Silico Analysis
Taibi, M.
Elbouzidi, A.
Baraich, A.
Haddou, M.
Loukili, E.
Bellaouchi, R.
Saalaoui, E.
Asehraou, A.
Addi, M.
Bourhia, M.
El Guerrouj, B.
Chaabane, K.
MOROCCAN JOURNAL OF CHEMISTRY, 2024, 12 (03): : 997 - 1021
[2] Chemical Composition, Antifungal and Insecticidal Activities of the Essential Oils from Tunisian Clinopodium nepeta subsp. nepeta and Clinopodium nepeta subsp. glandulosum
Debbabi, Haifa
El Mokni, Ridha
Chaieb, Ikbal
Nardoni, Simona
Maggi, Filippo
Caprioli, Giovanni
Hammami, Saoussen
MOLECULES, 2020, 25 (09):
[3] PHYTOCHEMICAL COMPOSITION, ANTIBACTERIAL EFFICACY, AND SYNERGISTIC INTERACTIONS OF CLINOPODIUM NEPETA SUBS ASCENDENS ESSENTIAL OIL IN COMBINATION WITH CONVENTIONAL ANTIBIOTICS
Taibi, M.
ElBouzidi, A.
Haddou, M.
Belbachir, Y.
Baraich, A.
Loukili, E. H.
Yahyaoui, M., I
Bentouhami, N. E.
Moumnassi, S.
Bellaouchi, R.
Asehraou, A.
Capanoglu, E.
Addi, M.
Bourhia, M.
Ibenmoussa, S.
Salamatullah, A. M.
El Guerrouj, B.
Chaabane, K.
APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH, 2024, 22 (05): : 4101 - 4114
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Debbabi, Haifa
El Mokni, Ridha
Nardoni, Simona
Chaieb, Ikbal
Maggi, Filippo
Nzekoue, Franks Kamgang
Caprioli, Giovanni
Hammami, Saoussen
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2021, 28 (11) : 13624 - 13633
[5] Chemical diversity and biological activities of essential oils from native populations of Clinopodium menthifolium subsp. ascendens (Jord.) Govaerts
Haïfa Debbabi
Ridha El Mokni
Simona Nardoni
Ikbal Chaieb
Filippo Maggi
Franks Kamgang Nzekoue
Giovanni Caprioli
Saoussen Hammami
Environmental Science and Pollution Research, 2021, 28 : 13624 - 13633
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Ambrico A.
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Sharma N.
Organic Agriculture, 2020, 10 (1) : 35 - 48
[7] Yield and Composition of the Essential Oil of Clinopodium nepeta subsp. spruneri as Affected by Harvest Season and Cultivation Method, i.e., Outdoor, Greenhouse and In Vitro Culture
Vlachou, Georgia
Papafotiou, Maria
Daferera, Dimitra J.
Tarantilis, Petros A.
PLANTS-BASEL, 2023, 12 (24):
[8] Investigation of the phytochemicals and bioactivity potential of essential oil from Nepeta curvidens Boiss. & Balansa
Ashrafi, Behnam
Rashidipour, Marzieh
Gholami, Elham
Sattari, Ehsan
Marzban, Abdolrazagh
Kheirandish, Farnaz
Khaksarian, Mojtaba
Taherikalani, Morovat
Soroush, Setareh
SOUTH AFRICAN JOURNAL OF BOTANY, 2020, 135 : 109 - 116
[9] Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Ptychotis verticillata Duby: Anti-diabetic, anti-tyrosinase, and anti-inflammatory activity
Taibi, Mohamed
Elbouzidi, Amine
Haddou, Mounir
Baraich, Abdellah
Loukili, El Hassania
Moubchir, Tarik
Allali, Aimad
Khoulati, Amine
Bellaouchi, Reda
Asehraou, Abdeslam
Addi, Mohamed
Salamatullah, Ahmad Mohammad
Bourhia, Mohammed
Siddique, Farhan
El Guerrouj, Bouchra
Chaabane, Khalid
HELIYON, 2024, 10 (08)
[10] Essential oil constituents, antimicrobial and herbicidal assays of lesser calamint (Calamintha nepeta (L.) Savi subsp. nepeta) from East Mediterranean Region of Turkey
Ulukanli, Zeynep
Demirci, Salih Cercis
Yilmaztekin, Murat
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2016, 6 (06): : 1867 - 1871

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