Cardiovascular and lifestyle risk factors of mild cognitive impairment in UK veterans and non-veterans

Background The link between poor cardiovascular health (CVH), lifestyle and mild cognitive impairment (MCI) has been well established in the general population. However, there is limited research exploring these associations in ageing UK veterans.Aims This study explored the risk of MCI and its association with nine CVH and lifestyle risk factors (including diabetes, heart disease, high cholesterol, high blood pressure, obesity, stroke, physical inactivity, the frequency of alcohol consumption and smoking) in UK veterans and non-veterans.Methods This prospective cohort study comprised data from the PROTECT study between 2014 and 2022. Participants comprised of UK military veterans and non-veterans aged >= 50 years at baseline. Veteran status was defined using the Military Service History Questionnaire. CVH and lifestyle risk factors were defined using a combination of self-report measures, medication history or physical measurements. MCI was defined as the presence of subjective and objective cognitive impairment.Results Based on a sample of 9378 veterans (n = 488) and non-veterans (n = 8890), the findings showed the risk of MCI significantly reduced in veterans with obesity, those who frequently consumed alcohol and were physically inactive compared to non-veterans. The risk of MCI significantly increased in veterans with diabetes (hazards ratio [HR] = 2.22, 95% confidence interval [CI] 1.04-4.75, P <= 0.05) or high cholesterol (HR = 3.11, 95% CI 1.64-5.87, P <= 0.05) compared to veterans without.Conclusions This study identified CVH and lifestyle factors of MCI in UK veterans and non-veterans. Further work is needed to understand these associations and the underpinning mechanisms which could determine intervention strategies to reduce the risk of MCI. Research has shown cardiovascular health (CVH) and lifestyle risk factors increase the risk of mild cognitive impairment (MCI) in the ageing general population. However, this information is limited in the ageing veteran population. As no studies have compared the risk of MCI between veterans and non-veterans in the UK, this presents an opportunity to conduct the first comparative study using a UK cohort of 9378 individuals aged 50 years and over.