Oxytocin and vasopressin signaling in health and disease

被引：5

作者：

Perisic, Monika ^{[1
,2
]}

Woolcock, Katrina ^{[1
]}

Hering, Anke ^{[3
]}

Mendel, Helen ^{[3
]}

Muttenthaler, Markus ^{[1
,3
]}

机构：

[1] Univ Vienna, Inst Biol Chem, Fac Chem, A-1090 Vienna, Austria

[2] Univ Vienna, Vienna Doctoral Sch Chem, A-1090 Vienna, Austria

[3] Univ Queensland, Inst Mol Biosci, Brisbane 4072, Australia

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2024年 / 49卷 / 04期

基金：

澳大利亚研究理事会; 欧洲研究理事会;

关键词：

RECEPTOR ANTAGONIST; SELECTIVE AGONISTS; BETA-ARRESTIN; PHARMACOLOGICAL CHARACTERIZATION; ARGININE-VASOPRESSIN; SOCIAL AVOIDANCE; V-1B RECEPTOR; V1B RECEPTORS; POTENT; DESIGN;

D O I：

10.1016/j.tibs.2024.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurohypophysial peptides are ancient and evolutionarily highly conserved neuropeptides that regulate many crucial physiological functions in vertebrates and invertebrates. The human neurohypophysial oxytocin/vasopressin (OT/VP) signaling system with its four receptors has become an attractive drug target for a variety of diseases, including cancer, pain, cardiovascular indications, and neurological disorders. Despite its promise, drug development faces hurdles, including signaling complexity, selectivity and off -target concerns, translational interspecies differences, and inefficient drug delivery. In this review we dive into the complexity of the OT/VP signaling system in health and disease, provide an overview of relevant pharmacological probes, and discuss the latest trends in therapeutic lead discovery and drug development.

引用

页码：361 / 377

页数：17

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