Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

被引：2

作者：

Venkatraman, Rajendran ^{[1
]}

Divya, Jaganathan ^{[1
]}

Gayathri, Pannerselvam ^{[1
]}

Thirunarayanan, Ganesamoorthy ^{[2
]}

Muthuvel, Inbasekaran ^{[1
,2
]}

机构：

[1] Annamalai Univ, Dept Chem, Annamalainagar, India

[2] MR Govt Arts Coll, Dept Chem, Mannargudi 614001, India

来源：

OVIDIUS UNIVERSITY ANNALS OF CHEMISTRY | 2024年 / 35卷 / 01期

关键词：

pyrimidinethiones; acetonaphthones; thiourea; NMR spectra; antibacterial activity; PHARMACOLOGICAL EVALUATION; CHALCONE DERIVATIVES; ANALOGS;

D O I：

10.2478/auoc-2024-0005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1H)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the in vitro antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method.

引用

页码：36 / 42

页数：7

共 50 条

[1] Synthesis and Biological Evaluation of Some Novel 6-(Substituted Phenyl)-4-(10H-Phenothiazin-10-YL)Pyrimidin-2(1H)-Ones/Thiones
T. N. Bansode
R. P. Rangari
P. A. Shimpi
Pharmaceutical Chemistry Journal, 2014, 48 : 430 - 433
[2] Synthesis and Biological Evaluation of Some Novel 6-(Substituted Phenyl)-4-(10H-Phenothiazin-10-YL)Pyrimidin-2(1H)-Ones/Thiones
Bansode, T. N.
Rangari, R. P.
Shimpi, P. A.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 48 (07) : 430 - 433
[3] SIMPLE AND REGIOSELECTIVE SYNTHESIS OF N-SUBSTITUTED PYRIMIDINE-2(1H)-ONES AND PYRIMIDINE-2(1H)-THIONES
BARLUENGA, J
TOMAS, M
RUBIO, V
GOTOR, V
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (16) : 675 - 676
[4] Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho [2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives
Gaikwad, Sanjeevan S.
Suryawanshi, Venkat S.
Lohar, Kishan S.
Jadhav, Dhanaji V.
Shinde, Narayan D.
E-JOURNAL OF CHEMISTRY, 2012, 9 (01) : 175 - 180
[5] Ethyl 6-(6-methoxynaphthalen-2-yl)-4-naphthalen-2-yl)-2-oxocyclohex-3-ene-1-carboxylate
Kaur, Manpreet
Jasinski, Jerry P.
Keeley, Amanda C.
Yathirajan, H. S.
Mayekar, Anil N.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O352 - +
[6] Synthesis of some 4-(2-hydroxy phenyl)-6-(1,3-diphenyl-1H-pyrazol-4-yl) pyrimidine-2(1H)-thiones and 2(5-(1,3-diphenyl-1H-pyrazol-4-yl)-1H- pyrazol-3-yl) phenols
Pawar, SB
Dalvi, NR
Karale, BK
Gill, CH
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 15 (02) : 197 - 198
[7] SYNTHESIS AND EVALUATION OF 5-(6-METHOXYNAPHTHALEN-2-YL)-1-ARYL-1-(4-(TRIFLUOROMETHYL)PHENYLAMINO)PENTAN-3-ONE AS POTENTIAL ANTIDIABETIC AGENTS
Han Hai-Yan
Yan Ju-Fang
Xu Jin
Ye Fei
Fan Li
Zhou Guang-Ming
Yang Da-Cheng
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2011, 56 (04): : 930 - 934
[8] Synthesis and Antibacterial Activity of 6-(5′-Substituted-2′-benzofuryl)-4-aryl-4H-2-oxopyrimidines
Jadhav, D. V.
Choudhari, J. R.
Patil, L. S.
Shinde, N. D.
ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (07) : 5443 - 5446
[9] Multicomponent one-pot synthesis, characterization and antimicrobial screening of 2 cyanoimino-6-aryl-4-(6-methoxynaphthalen-2-yl)-3, 4-dihydro-1H-pyrimidines
Sivagami, Swaminathan
Kavitha, Rengarajan
Satanathan, Sasikurba
Rajesh, Jegathalaprathaban
Narenkumar, Jayaraman
Parthipan, Punniyakotti
Muthusamy, Karnan
Alfarhan, Ahmed
PROCESS BIOCHEMISTRY, 2022, 123 : 63 - 69
[10] Synthesis of 2-Arylaminopyrimidines from 1,4,6-Trisubstituted Pyrimidine-2(1H)-Thiones
Muceniece, D.
Kodolins, O.
Lusis, V.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2014, 49 (11) : 1658 - 1666

← 1 2 3 4 5 →