Calcium(II)-Mediated Three-Component Selenylation of gem-Difluoroalkenes: Access to α,α-Difluoroalkyl-β-selenides

被引：0
|
作者：
Kuang, Minyao [1 ,2 ,3 ]
Chen, Haokun [1 ,2 ,3 ]
Liu, Yuwei [1 ,2 ,3 ]
Huang, Jianlian [1 ,2 ,3 ]
Zeng, Zhongyi [1 ,2 ,3 ]
Zhou, Zhi [1 ,2 ,3 ]
Li, Haoran [1 ,2 ,3 ]
Yi, Wei [1 ,2 ,3 ]
Wang, Shengdong [1 ,2 ,3 ]
机构：
[1] Guangzhou Med Univ, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 29期
关键词：
ALKENES; AMIDOSELENATION; SULFAMIDES; SELENIDES; CHEMISTRY; ACIDS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A calcium-mediated three-component selenylation of gem-difluoroalkenes using alcohols as nucleophiles and N-(phenylseleno)phthalimide as the selenylation agent has been developed for the efficient synthesis of various alpha,alpha-difluoroalkyl-beta-selenides. This selenylation reaction exhibits broad substrate and functional group tolerance, along with high levels of chemo- and regioselectivity. Additionally, the synthetic utility of the developed transformation in the late-stage functionalization of drug molecules was demonstrated.
引用
收藏
页码：6274 / 6278
页数：5
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