Research purposes: Safety accidents in subway shield construction have increased in recent years and they caused huge losses to government, industry, enterprise, and individuals. To prevent the safety accident in subway shield construction, this paper investigated the safety impact factors and accident causation model. We proposed an analytical framework for safety impact factors using system engineering method of human-machine-environment and identified key safety impact factors based on literature review, case analysis and expert interview. The safety accident causation model was constructed based on DEMATEL-ISM method. And then, HF sub-project was chosen for case study to test the applicability of the safety accident causation model. Research conclusions:(1) The safety impact factors in the subway shield construction can be systematically identified as personnel, mechanic-equipment and environmental impact factors. (2) Safety accident causation of subway shield construction can be interpreted by five-tier system model, of which accident-causing situations are the direct factors. (3) Safety plan, safety inspection and worker safety competencies are the pivot nodes. (4) The causation model proposed in this research can guide the safety management during subway shield construction. © 2020, Editorial Department of Journal of Railway Engineering Society. All right reserved.