Archimedean heterologous helixes in Ti10Cd6-oxo nanoclusters: double-helical self-assembly and therapeutic application in Parkinson's disease

被引：1

作者：

Meng, Ling-Cui ^{[1
]}

Chen, Jun-Yi ^{[2
]}

Feng, Zhi-Ming ^{[1
]}

Jiang, Zhan-Guo ^{[1
]}

Jin, Zhigang ^{[2
]}

Zhan, Cai-Hong ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Coll Chem & Mat Sci, Inst Phys Chem, Key Lab Minist Educ Adv Catalysis Mat, Jinhua 321004, Peoples R China

[2] Zhejiang Normal Univ, Coll Life Sci, Jinhua 321004, Peoples R China

来源：

INORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 12期

基金：

中国国家自然科学基金;

关键词：

POLYPYRIDYL COMPLEX; FRAMEWORKS; NANOPARTICLES; AGGREGATION; ENANTIOMERS; CLUSTER; IONS;

D O I：

10.1039/d4qi00890a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The construction of spiral nanostructures has been a long and challenging pursuit. Herein, we report a helical cadmium doping titanium-oxo cluster (Ti10Cd6), which can be extracted from Archimedean spiral curves using the equation r = 1 + 1.5 theta (theta = 0-350 degrees). A heterologous helix as the building block is further assembled into a double-stranded helical superstructure through intra- and inter-strand non-covalent interactions. Furthermore, the enantioseparation of the novel helix was realized through chiral ligand exchange. Moreover, biological application of the enantiomer R-/S-Ti10Cd6 was studied, and the results show that R-Ti10Cd6 significantly ameliorates the degeneration of dopaminergic neurons compared to S-Ti10Cd6 in a C. elegans model of Parkinson's disease, suggesting an important role of chirality in biomedical applications of metal-oxo clusters.

引用

页码：3527 / 3537

页数：11