Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis

被引：0

作者：

Fujita, Hiroaki ^{[1
]}

Iwai, Kazuhiro ^{[1
]}

机构：

[1] Kyoto Univ, Kyoto, Japan

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2024年 / 31卷 / 08期

关键词：

MECHANISMS;

D O I：

10.1038/s41594-024-01330-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An iron-induced ferroptosis screen revealed PRDX6 as a selenoprotein-synthesis factor. Loss of PRDX6 substantially decreased expression of the selenoprotein GPX4, a master regulator of ferroptosis, and induced ferroptosis. Mechanistically, PRDX6 increases the efficiency of selenium use by acting as a selenium delivery protein.

引用

页码：1154 / 1155

页数：2

共 16 条

[1] PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis
Fujita, Hiroaki
Tanaka, Yu-ki
Ogata, Seiryo
Suzuki, Noriyuki
Kuno, Sota
Barayeu, Uladzimir
Akaike, Takaaki
Ogra, Yasumitsu
Iwai, Kazuhiro
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2024, 31 (08) : 1277 - 1285
[2] PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization
Ito, Junya
Nakamura, Toshitaka
Toyama, Takashi
Chen, Deng
Berndt, Carsten
Poschmann, Gereon
Mourao, Andre Santos Dias
Doll, Sebastian
Suzuki, Mirai
Zhang, Weijia
Zheng, Jiashuo
Trumbach, Dietrich
Yamada, Naoya
Ono, Koya
Yazaki, Masana
Kawai, Yasutaka
Arisawa, Mieko
Ohsaki, Yusuke
Shirakawa, Hitoshi
Wahida, Adam
Proneth, Bettina
Saito, Yoshiro
Nakagawa, Kiyotaka
Mishima, Eikan
Conrad, Marcus
MOLECULAR CELL, 2024, 84 (23)
[3] Identification of PRDX6 as a regulator of ferroptosis
Lu, Bin
Chen, Xiao-bing
Hong, Yu-cai
Zhu, Hong
He, Qiao-jun
Yang, Bo
Ying, Mei-dan
Cao, Ji
ACTA PHARMACOLOGICA SINICA, 2019, 40 (10) : 1334 - 1342
[4] Identification of PRDX6 as a regulator of ferroptosis
Bin Lu
Xiao-bing Chen
Yu-cai Hong
Hong Zhu
Qiao-jun He
Bo Yang
Mei-dan Ying
Ji Cao
Acta Pharmacologica Sinica, 2019, 40 : 1334 - 1342
[5] PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance
Chen, Zhiyi
Inague, Alex
Kaushal, Kamini
Fazeli, Gholamreza
Schilling, Danny
da Silva, Thamara N. Xavier
dos Santos, Ancely Ferreira
Cheytan, Tasneem
Freitas, Florencio Porto
Yildiz, Umut
Viviani, Lucas Gasparello
Lima, Rodrigo Santiago
Pinz, Mikaela Peglow
Medeiros, Isadora
Iijima, Thais Satie
Alegria, Thiago Geronimo Pires
da Silva, Railmara Pereira
Diniz, Larissa Regina
Weinzweig, Simon
Klein-Seetharaman, Judith
Trumpp, Andreas
Manas, Adriana
Hondal, Robert
Bartenhagen, Christoph
Fischer, Matthias
Shimada, Briana K.
Seale, Lucia A.
Chillon, Thilo Samson
Fabiano, Marietta
Schomburg, Lutz
Schweizer, Ulrich
Netto, Luis E.
Meotti, Flavia C.
Dick, Tobias P.
Alborzina, Hamed
Miyamoto, Sayuri
Angeli, Jose Pedro Friedmann
MOLECULAR CELL, 2024, 84 (23)
[6] PRDX6 alleviates lipopolysaccharide-induced inflammation and ferroptosis in periodontitis
Yang, Wen-Ying
Meng, Xiang
Wang, Yue-Rong
Wang, Qing-Qing
He, Xin
Sun, Xiao-Yu
Cheng, Nan
Zhang, Lei
ACTA ODONTOLOGICA SCANDINAVICA, 2022, 80 (07) : 535 - 546
[7] The effects and mechanisms of PRDX6 on alleviating epithelial ferroptosis in COPD through enhancing the stability of ferritin and inhibiting its ferritinophagy
Wei, Tingting
Wang, Xiaocen
Lang, Ke
Yang, Dong
EUROPEAN RESPIRATORY JOURNAL, 2024, 64
[8] Integrated bioinformatics and machine learning strategies reveal PRDX6 as the key ferroptosis-associated molecular biosignature of heart failure
Jiang, Chenyang
Jiang, Weidong
GENERAL PHYSIOLOGY AND BIOPHYSICS, 2022, 41 (05) : 365 - +
[9] The BMSC-derived exosomal lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis
Zhang, Jian-Kai
Zhang, Zhi
Guo, Zi-Ao
Fu, Yuan
Chen, Xiao-Jia
Chen, Wei-Jie
Wu, Hong-Fu
Cui, Xiao-Jun
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2022, 32 (02) : 515 - 527
[10] Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis
Zhang, Qianjin
Hu, Yichuan
Hu, Jin-E
Ding, Ying
Shen, Yanqiu
Xu, Hong
Chen, Huiqin
Wu, Ning
LIFE SCIENCES, 2021, 278

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