Antiplatelet Therapy and Anticoagulation before, during, and after Acute Coronary Syndrome

被引:2
|
作者
Kaufmann, Christoph C. [1 ,2 ]
Muthspiel, Marie [1 ,2 ]
Lunzer, Laura [1 ]
Pogran, Edita [1 ,2 ]
Zweiker, David [1 ]
Burger, Achim Leo [1 ,2 ]
Wojta, Johann [3 ,4 ,5 ]
Huber, Kurt [1 ,2 ,3 ]
机构
[1] Klin Ottakring Wilhelminenhosp, 3rd Med Dept Cardiol & Intens Care Med, A-1160 Vienna, Austria
[2] Sigmund Freud Univ, Fac Med, A-1020 Vienna, Austria
[3] Ludwig Boltzmann Inst Cardiovasc Res, A-1090 Vienna, Austria
[4] Med Univ Vienna, Core Facil, A-1090 Vienna, Austria
[5] Med Univ Vienna, Dept Internal Med 2, Div Cardiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria
关键词
acute coronary syndrome; myocardial infarction; antiplatelet therapy; anticoagulation; antithrombotic therapy; ELEVATION MYOCARDIAL-INFARCTION; ATRIAL-FIBRILLATION; OPEN-LABEL; TICAGRELOR MONOTHERAPY; ANTITHROMBOTIC THERAPY; CARDIOVASCULAR EVENTS; PLATELET INHIBITION; DE-ESCALATION; INTERVENTION; CLOPIDOGREL;
D O I
10.3390/jcm13082313
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute coronary syndrome (ACS) remains a major challenge in clinical practice, requiring rapid and effective antithrombotic treatment to mitigate adverse ischemic events while minimizing the risk of bleeding. In recent years, results from several clinical trials addressing this issue through various approaches have substantially improved the treatment landscape for patients presenting with ACS. The emergence of new, potent P2Y12 inhibitors has significantly enhanced thrombotic risk reduction and different strategies for de-escalating and shortening dual antiplatelet therapy (DAPT) have demonstrated promising outcomes in reducing bleeding rates. Furthermore, data from ongoing trials focusing on novel therapeutic agents and investigating alternative treatment strategies to optimize outcomes for ACS patients are expected in the next few years. In this review, we summarize the current knowledge and emphasize the critical role of individualized treatment approaches tailored to patient-specific risk factors and individual clinical scenarios.
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收藏
页数:17
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