Hearing disorders, genetic predisposition, and risk of new-onset atrial fibrillation: A prospective cohort study in the UK biobank

被引:1
|
作者
Hou, Yabing [1 ]
Yang, Hongxi [2 ]
Xu, Yanning [3 ,4 ]
Wang, Kan [4 ]
Fu, Yinghong [1 ]
Lu, Zuolin [5 ]
机构
[1] Capital Med Univ, Yanjing Med Coll, Dept Med Informat Technol & Management, Beijing, Peoples R China
[2] Tianjin Med Univ, Sch Basic Med Sci, Dept Bioinformat, Tianjin, Peoples R China
[3] Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands
[4] Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands
[5] Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Beijing 100730, Peoples R China
基金
中国国家自然科学基金;
关键词
Atrial fibrillation; Hearing difficulty; Tinnitus; Genetic risk score; population -based study; STRESS;
D O I
10.1016/j.ijcard.2024.131829
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Hearing impairment has been linked to several cardiovascular diseases. However, the association between hearing disorders, genetic predisposition, and new -onset AF remains largely unknown. Methods: A total of 476,773 participants (mean age 56.5 years) free of AF at baseline (from 2006 to 2010) were included from the UK Biobank study. The presence of hearing disorders including hearing difficulty and tinnitus was self -reported through the touchscreen questionnaire. AF was defined using ICD-10 code: I48 and was followed till February 1st. 2022. The Cox model was used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CI). Results: During a median follow-up of 13.0 years, the AF incidence rate was 2.9 per 1000 person -years. After adjustments for potential confounders, the presence of hearing difficulty (HR, 1.35; 95% CI: 1.32-1.39) and the use of hearing aid (1.45; 1.37-1.53) were significantly associated with risk of new -onset AF. Compared to individuals without tinnitus, the AF risk increased by 17% among those who experienced tinnitus occasionally (1.17; 1.09-1.25), 23% among those who experienced tinnitus frequently (1.23; 1.10-1.39), and 32% among those who experienced tinnitus consistently (1.32; 1.22-1.42). No significant difference was observed across different groups of genetic risk score for AF onset. Conclusions: Our study provides evidence regarding significant associations of hearing difficulty, use of hearing aid, and tinnitus with risk of incident AF. Findings highlight the potential that screening hearing disorders can benefit AF prevention.
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页数:6
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