Aging insights from heterochronic parabiosis models

被引：1
|
作者：
Lagunas-Rangel, Francisco Alejandro [1 ]
机构：
[1] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
来源：
NPJ AGING | 2024年 / 10卷 / 01期
关键词：
COGNITIVE FUNCTION; SKELETAL-MUSCLE; GROWTH-FACTOR; YOUNG; BLOOD; GDF11; REJUVENATION; BETA-2-MICROGLOBULIN; METABOLISM; PREGNANCY;
D O I：
10.1038/s41514-024-00166-0
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Heterochronic parabiosis consists of surgically connecting the circulatory systems of a young and an old animal. This technique serves as a model to study circulating factors that accelerate aging in young organisms exposed to old blood or induce rejuvenation in old organisms exposed to young blood. Despite the promising results, the exact cellular and molecular mechanisms remain unclear, so this study aims to explore and elucidate them in more detail.
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页数：13
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