Effect of Gypenosicles Diet Intervention on Obesity Control and Gut Microbiota Regulation in Mice

被引：0

作者：

Jiaping L. ^{[1
]}

Bo W. ^{[1
]}

Xiaowei Z. ^{[1
]}

Yaqiong Z. ^{[1
]}

Liangli Y. ^{[2
]}

机构：

[1] School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai

[2] Department of Nutrition and Food Science, University of Maryland, College Park, 20742, MD

来源：

Journal of Chinese Institute of Food Science and Technology | 2022年 / 22卷 / 07期

关键词：

diet intervention; gut microbiota; gypenosides; obesity;

D O I：

10.16429/j.1009-7848.2022.07.009

中图分类号：

学科分类号：

摘要：

Gypenosides are the main bioactive components in Gvnostemma pentaphyllum. This study investigated whether gypenosicles diet intervention could reduce the development of overweight and regulate the gut microbiota in C57R1/6J mice, which were fed with a high-fat diet for 12 weeks. The results showed that gypenosides diet intervention at 600 mg/kg bw/d significantly reduced body weight gain, body lal percentage and adipocyte size in mice, compared with the high-fat diet group. Meanwhile, it also reduced low-density lipoprotein cholesterol, alanine aminotransferase and leptin, and increased high-density lipoprotein cholesterol. Moreover, the results of 16S rRNA high-throughput sequencing showed that gypenosides diet intervention increased the a diversity and relative abundance of Oscillospiraceae, Alloprevotella, Parabacteroides, Lachnospiraceae DW59 and Burkholderiales YL45 at genus level. © 2022 Chinese Institute of Food Science and Technology. All rights reserved.

引用

页码：88 / 96

页数：8

共 29 条

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