Effect of Theasaponin on Blood Glucose in Streptozocin-Induced Diabetic Rats

被引：1

作者：

Liu Z. ^{[1
]}

Lin L. ^{[1
]}

Lei Z. ^{[1
]}

Zeng W. ^{[1
]}

Cheng F. ^{[1
]}

Lin Q. ^{[1
]}

Yang J. ^{[1
]}

机构：

[1] Key Laboratory of Tea Science at University in Fujian, College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou

来源：

Shipin Kexue/Food Science | 2020年 / 41卷 / 19期

关键词：

Hypoglycemic effect; Tea tree; Theasaponin; Type 2 diabetes mellitus;

D O I：

10.7506/spkx1002-6630-20190624-283

中图分类号：

学科分类号：

摘要：

Objective: To investigate the hypoglycemic effect of theasaponin on a type 2 diabetic rat model. Methods: The rat model was established by feeding of a high-fat diet combined with intraperitoneal injection of streptozotocin (STZ). Fasting blood glucose, glucose tolerance, and blood lipids were measured after 40 days of continuous administration of theasaponin.Liver function and other related indicators were observed. Results: Theasaponin could effectively regulate hyperglycemia and dyslipidemia in type 2 diabetic rats, and significantly improve serum total cholestrol (TC), triglyceride (TG), highdensity lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (P < 0.01). Furthermore, it could significantly decrease the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum(P < 0.01) and repair the morphology of islet and liver tissue in diabetic rats. Conclusion: Theasaponin at a certain dose(50-150 mg/(kg mb d)) has obvious hypoglycemic effects on the STZ-induced type 2 diabetic rat model. © 2020, China Food Publishing Company. All right reserved.

引用

页码：179 / 184

页数：5

共 12 条

[1] ZHENG J S, LIN M, FANG L., Effects of n-3 fatty acid supplements on glycemic traits in Chinese type 2 diabetic patients: a double-blind randomized controlled trial, Molecular Nutrition & Food Research, 60, 10, pp. 2176-2184, (2016)
[2] RAZ I, ELDOR R., Rational therapy for diabetes: early recognition of adverse effects and avoidance of disruptive false alarms, Diabetes-Metabolism Research and Reviews, 28, 4, pp. 321-324, (2012)
[3] KIM J D, CHAUDHARY N, SEO H J, Et al., Theasaponin E<sub>1</sub> as an effective ingredient for anti-angiogenesis and anti-obesity effects, Journal of the Agricultural Chemical Society of Japan, 78, 2, pp. 279-287, (2014)
[4] ZHAO W, LI N, ZHANG X, Et al., Cancer chemopreventive theasaponin derivatives from the total tea seed saponin of Camellia sinensis[J], Journal of Functional Foods, 12, 1, pp. 192-198, (2015)
[5] CHEN X, LIN Z, YE Y, Et al., Suppression of diabetes in non-obese diabetic (NOD) mice by oral administration of water-soluble and alkali-soluble polysaccharide conjugates prepared from green tea, Carbohydrate Polymers, 82, 1, pp. 28-33, (2010)
[6] FU Q, LI Q, LIN X, Et al., Antidiabetic effects of tea, Molecules, 22, 5, (2017)
[7] 11
[8] KEYHANI-NEJAD F, IRMLER M, ISKEN F, Et al., Nutritional strategy to preventfatty liver and insulin resistance independent of obesity by reducingglucose-dependent insulinotropic polypeptide responses in mice, Diabetologia, 58, 2, pp. 374-383, (2015)
[9] 3
[10] KITABCHI A E, MARINELLA T, KNOWLER W C, Et al., Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin, Diabetes, 54, 8, pp. 2404-2414, (2005)

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