Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds

被引：2
|
作者：
Kabieva, Saule [1 ]
Zhumanazarova, Gaziza [1 ]
Zhaslan, Rymgul [1 ]
Zhumabayeva, Gulistan [2 ]
Ukhov, Arthur [3 ]
Fedorishin, Dmitry [3 ]
Gubankov, Alexander [3 ]
Tarikhov, Farkhad [3 ]
Yerkhan, Ordabay [2 ]
Irina, Kurzina [3 ]
Yerkassov, Rakhmetulla [2 ]
Bakibaev, Abdigali [3 ]
机构：
[1] Karaganda Ind Univ, Dept Chem Technol & Ecol, Temirtau 101400, Kazakhstan
[2] LN Gumilyov Eurasian Natl Univ, Fac Nat Sci, St Satbaeva 2, Astana 010000, Kazakhstan
[3] Natl Res Tomsk State Univ, Chem Fac, Arkady Ivanov St 49, Tomsk 634050, Russia
来源：
MOLECULES | 2024年 / 29卷 / 07期
基金：
俄罗斯科学基金会;
关键词：
diatomite; betulin; chloramphenicol; tetrahydroxymethylglycoluril; biocompatible materials; antibacterial activity;
D O I：
10.3390/molecules29071608
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aimed to create new composite materials based on diatomite-a non-organic porous compound-through its surface modification with bioactive organic compounds, both synthetic and natural. Chloramphenicol, tetrahydroxymethylglycoluril and betulin were used as modifying substances. Composite materials were obtained by covering the diatomite surface with bioactive substance compounds as a solution and material dispersion in it. The materials were characterized by IR spectroscopy, SEM and X-ray photoelectron spectroscopy. For the biocomposites, the hemolytic effect, plasma proteins' adsorption on the surface and the antibacterial activity of the obtained materials were studied. Results show that the obtained materials are promising for medicine and agriculture.
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页数：20
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