Grain versus AIN: Common rodent diets differentially affect health outcomes in adult C57BL/6j mice

被引:3
|
作者
Schipper, Lidewij [1 ]
Tims, Sebastian [1 ]
Timmer, Eva [1 ]
Lohr, Julia [1 ]
Rakhshandehroo, Maryam [1 ]
Harvey, Louise [1 ]
机构
[1] Danone Nutr Res, Utrecht, Netherlands
来源
PLOS ONE | 2024年 / 19卷 / 03期
关键词
PURIFIED DIET; CD-1; MICE; RATS; WEIGHT; GROWTH; FIBER;
D O I
10.1371/journal.pone.0293487
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Semi-synthetic and grain-based diets are common rodent diets for biomedical research. Both diet types are considered nutritionally adequate to support breeding, growth, and long life, yet there are fundamental differences between them that may affect metabolic processes. We have characterized the effects of diet type on breeding outcomes, metabolic phenotype, and microbiota profile in adult mice. Healthy 8-week-old female and male C57BL/6J mice were fed a semi-synthetic or a grain-based diet for 12 weeks and changes in body weight and body composition were monitored. Breeding outcomes were determined. Body fat accumulation of female mice was lower on the semi-synthetic diet than on the grain-based diet. Pregnancy rate and newborn pup survival appeared to be lower in mice exposed to semi-synthetic diet compared to grain-based diet. Both female and male mice showed a profound change in fecal microbiota alpha and beta diversity depending on diet type. Our study shows that type of rodent diet may affect breeding outcomes whilst influencing metabolism and health of female laboratory mice. These factors have the potential to influence other experimental outcomes and the results suggest that semi-synthetic and grain-based diets are not interchangeable in research using rodent models. Careful consideration and increased understanding of the consequences of diet choice would lead to improvements in experimental design and reproducibility of study results.
引用
收藏
页数:22
相关论文
共 50 条
  • [1] ATHEROGENESIS IN UREMIC C57BL/6J MICE
    STEWARTPHILLIPS, JL
    GAGNON, RF
    LOUGH, J
    SOMERVILLE, P
    KIDNEY INTERNATIONAL, 1989, 35 (01) : 201 - 201
  • [2] MORTALITY CHARACTERISTIC OF C57BL/6J MICE
    不详
    ZEITSCHRIFT FUR VERSUCHSTIERKUNDE, 1971, 13 (04): : 239 - &
  • [3] Observational learning in C57BL/6j mice
    Carlier, Pascal
    Jamon, Marc
    BEHAVIOURAL BRAIN RESEARCH, 2006, 174 (01) : 125 - 131
  • [4] Metabolic differences and differentially expressed genes between C57BL/6J and C57BL/6N mice substrains
    Nemoto, Shino
    Kubota, Tetsuya
    Ohno, Hiroshi
    PLOS ONE, 2022, 17 (12):
  • [5] EARLY EXPERIENCE AND THE CONSUMPTION OF ALCOHOL BY ADULT C57BL/6J MICE
    HO, A
    CHIN, AJ
    DOLE, VP
    ALCOHOL, 1989, 6 (06) : 511 - 515
  • [6] Inhibitory Effects of Myriocin, Sphingolipid Biosynthesis Inhibitor, On Gallstone Formation in C57BL/6J Mice in C57BL/6J Mice
    Lee, Beom Jae
    Kim, Jae Seon
    Jung, Sung Joo
    Joo, Moon Kyung
    Hong, Seung Goun
    Kim, Benjamin
    Kim, Ji Hoon
    Yeon, Jong Eun
    Park, Jong-Jae
    Byun, Kwan Soo
    Bak, Young-Tae
    Oh, Seikwan
    Yoo, Hwan-Soo
    GASTROENTEROLOGY, 2009, 136 (05) : A1 - A1
  • [7] Immunomodulatory Effects of a New Thiazolidine Compound in C57BL/6J and C57BL/6J Ldlr -/- Mice with Metabolic Syndrome
    Silva, Jacqueline Cavalcante
    Mendes, Edson
    Cavalcante, Marcela Frota
    Pitta, Ivan da Rocha
    Parra Abdalla, Dulcineia Saes
    ENDOCRINE REVIEWS, 2014, 35 (03)
  • [8] Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice
    DeWitt, Jamie C.
    Copeland, Carey B.
    Strynar, Mark J.
    Luebke, Robert W.
    ENVIRONMENTAL HEALTH PERSPECTIVES, 2008, 116 (05) : 644 - 650
  • [9] Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice
    Blednov, YA
    Metten, P
    Finn, DA
    Rhodes, JS
    Bergeson, SE
    Harris, RA
    Crabbe, JC
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2005, 29 (11) : 1949 - 1958
  • [10] STUDIES OF AXONAL REGENERATION IN C57BL/6J AND A/J MICE
    LU, X
    SKAMENE, E
    RICHARDSON, PM
    BRAIN RESEARCH, 1994, 652 (01) : 174 - 176