Synthesis,Crystal Structure and Anti-tumor Activity of Ethyl 3-(4-methoxyphenyl)-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylate

被引：0

作者：

钟涵宇 ^{[1
]}

王甜甜 ^{[1
]}

张一凯 ^{[1
]}

陈焕 ^{[1
]}

吕志良 ^{[1
]}

张明峰 ^{[1
]}

耿冬平 ^{[1
]}

牛春娟 ^{[1
]}

李科 ^{[1
]}

机构：

[1] Department of Medicinal Chemistry,School of Pharmacy,Second Military Medical University

来源：

结构化学 | 2011年 / 30卷 / 12期

关键词：

3; 3a-dihydro-1H-furo[3; 4-c]pyran-4(6H)-one; synthesis; crystal structure; anti-tumor activity;

D O I：

暂无

中图分类号：

O621.3 [有机合成化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound(ethyl 3-(4-methoxyphenyl)-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylate) has been synthesized,and its crystal structure was characterized by X-ray single-crystal diffraction.The crystal belongs to monoclinic,space group P21/n,with a = 10.124(4),b = 11.754(4),c = 13.792(5) ,β = 111.533(3)o,V = 1526.6(10) 3,Z = 4,C17H19O6,Mr = 319.32,Dc = 1.389 g/cm3,F(000) = 676,λ(MoKα) = 0.71073 ,μ = 0.105 mm-1,R = 0.0660 and wR = 0.2027 for 2993 observed reflections(I > 2σ(I)).The compound shows potent anti-tumor activity in vitro.

引用

页码：1737 / 1741

页数：5

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