IN-VITRO ACTIVITY OF TYLOSIN AND ITS DERIVATIVES AGAINST UREAPLASMA-UREALYTICUM

被引：0
|
作者：
ZUZULOVA, M [1 ]
KLEINOVA, D [1 ]
PROKSA, B [1 ]
FUSKA, J [1 ]
机构：
[1] RES INST PREVENT MED, BRATISLAVA 83301, SLOVAKIA
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 1995年 / 45-2卷 / 11期
关键词：
ANTIBIOTICS; CAS; 1401-69-0; 1404-48-4; 11049-15-3; DESMYOCOSIN; LACTENOCIN; MACROCIN; MACROLIDE ANTIBIOTICS; 5-O-MYCAMINOSYL TYLONOLIDE; RELOMYCIN; TYLOSIN; DERIVATIVES; IN VITRO STUDIES;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antimicrobial activity of tylosin (CAS 1401-69-0) and five other 16-membered macrolides by biosynthesized by Streptomyces fradiae (lactenocin, desmycosin, macrocin (CAS 11049-15-3), relomycin (CAS 1404-48-4) and 5-O-mycaminosyl tylonolide) against Ureaplasma urealyticum was studied. The lowest minimum inhibitory concentrations (MIC) showed 5-O-mycaminosyl tylonolide tylosin and desmycosin. Absence of the aldehyde group in the structure of relomycin resulted in loss of the antimocrobial activity. Tylosin, desmycosin and macrocin proved better antimicrobial effect in the alkaline medium than in the acidic one.
引用
收藏
页码：1222 / 1224
页数：3
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