BEHAVIORAL-MODELS IN MICE - IMPLICATION OF THE ALPHA NORADRENERGIC SYSTEM

被引：28
|
作者：
HASCOET, M
BOURIN, M
BRADWEJN, J
机构：
[1] FAC MED NANTES,DEPT PHARMACOL & GIS MEDICAMENT,PHARMACOL LAB,F-44035 NANTES,FRANCE
[2] MCGILL UNIV,ST MARYS HOSP CTR,DEPT PSYCHIAT,MONTREAL H3A 2T5,QUEBEC,CANADA
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1991年 / 15卷 / 06期
关键词：
ALPHA-AGONISTS; ALPHA-BLOCKERS; FORCED SWIMMING TEST; SPONTANEOUS ACTIVITY; TAIL SUSPENSION TEST;
D O I：
10.1016/0278-5846(91)90011-O
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1. The mechanism of action of drugs might change according to the test used. Several noradrenergic drugs were tested in order to understand their implication in the mobility tests. 2. It was found that clonidine, an Alpha 2 agonist, acted differently according to the test used. It provoked sedation in spontaneous activity test, and anti-immobility effects in the other tests. 3. Tail suspension test is able to show the double acting of clonidine. 4. Idazoxan might act either as an alpha 2 antagonist or as partial alpha 2 agonist. TST shown the unexpected partial alpha agonist effect of the molecule. 5. Forced swimming test is more specific for predicting antidepressant activity than tail suspension test which is close to a spontaneous activity model.
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页码：825 / 840
页数：16
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