Nano SiO2 catalyzed synthesis of Imidazo [1,2-a] pyridines

被引:0
|
作者
Dharmana, Tejeswararao [1 ]
Kola, Koteswara Rao [1 ]
Bonnada, Nagamani Naidu [1 ]
机构
[1] GMR Inst Technol, Rajam 532127, Andhra Pradesh, India
来源
关键词
nano SiO2; microwave irradiation; Imidazo [1,2-a] pyridines; phenacyl bromide;
D O I
10.3166/ACSM.42.533-539
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A facile microwave assisted reaction of phenacyl bromide and 2-amino pyridine is catalyzed by Nano SiO2 under solvent free conditions to give corresponding Imidazo[1,2-a] pyridines in good yields. Reactions proceed with high efficiency and good functional group tolerance. This approach provides a useful protocol for the preparation of highly substituted Imidazo [1,2-a] pyridine derivatives.
引用
收藏
页码:533 / 539
页数:7
相关论文
共 50 条
  • [1] IMIDAZO[1,2-A]PYRIDINES .2. OZONOLYSIS OF IMIDAZO[1,2-A]PYRIDINES AND SYNTHESIS OF CARDIOTONIC AGENTS
    YAMANAKA, M
    SUDA, S
    YONEDA, N
    OHHARA, H
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (03) : 666 - 674
  • [2] SYNTHESIS OF IMIDAZO[1,2-A]PYRIDINES DIRECTLY FROM METHYLKETONES OR METHYLENEKETONES - IODATION OF IMIDAZO[1,2-A]PYRIDINES
    SALDABOL, NO
    HILLER, SA
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1976, (10): : 1396 - 1405
  • [3] Copper-Catalyzed Intermolecular Oxidative Cyclization of Haloalkynes: Synthesis of 2-Halo-substituted Imidazo[1,2-a]pyridines, Imidazo[1,2-a]pyrazines and Imidazo[1,2-a]pyrimidines
    Gao, Yang
    Yin, Meizhou
    Wu, Wanqing
    Huang, Huawen
    Jiang, Huanfeng
    ADVANCED SYNTHESIS & CATALYSIS, 2013, 355 (11-12) : 2263 - 2273
  • [4] Simple and Efficient One-Pot Synthesis of Imidazo[1,2-a]pyridines Catalyzed by Magnetic Nano-Fe3O4-KHSO4•SiO2
    Guntreddi, Tirumaleswararao
    Allam, Bharat Kumar
    Singh, Krishna Nand
    SYNLETT, 2012, (18) : 2635 - 2638
  • [5] An improved synthesis of 2-chlorinated imidazo[1,2-A]pyridines and the application of this procedure for the synthesis of several new polychlorinated imidazo[1,2-A]pyridines
    Gudmundsson, KS
    Drach, JC
    Townsend, LB
    SYNTHETIC COMMUNICATIONS, 1997, 27 (10) : 1763 - 1775
  • [6] Regioselective synthesis of pyrrolo[1,2-a]-imidazoles and imidazo[1,2-a]-pyridines
    Wang, Kai-Min
    Ma, Yu-Lu
    Lin, Xin-Rong
    Yan, Sheng-Jiao
    Lin, Jun
    RSC ADVANCES, 2015, 5 (46): : 36472 - 36479
  • [7] Synthesis of imidazo[1,2-a]pyridines as antiviral agents
    Gueiffier, A
    Mavel, S
    Lhassani, M
    Elhakmaoui, A
    Snoeck, R
    Andrei, G
    Chavignon, O
    Teulade, JC
    Witvrouw, M
    Balzarini, J
    De Clercq, E
    Chapat, JP
    JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (25) : 5108 - 5112
  • [8] Synthesis and antiviral activity of imidazo[1,2-a]pyridines
    Lhassani, M
    Chavignon, O
    Chezal, JM
    Teulade, JC
    Chapat, JP
    Snoeck, R
    Andrei, G
    Balzarini, J
    De Clercq, E
    Gueiffier, A
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (03) : 271 - 274
  • [9] Recent Developments in the Synthesis of Imidazo[1,2-a]pyridines
    Pericherla, Kasiviswanadharaju
    Kaswan, Pinku
    Pandey, Khima
    Kumar, Anil
    SYNTHESIS-STUTTGART, 2015, 47 (07): : 887 - 912
  • [10] An efficient synthesis of ferrocenyl imidazo[1,2-a]pyridines
    Roya Akbarzadeh
    Ghazaleh Imani Shakibaei
    Ayoob Bazgir
    Monatshefte für Chemie - Chemical Monthly, 2010, 141 : 1077 - 1081