Interleukin-8 concentrations in preeclamptic and healthy normotensive pregnant patients

被引：0
|
作者：
Reyna, E. [1 ]
Mejia, J. [1 ]
Reyna, N. [1 ]
Torres, D. [1 ]
Santos, J. [1 ]
Perozo, J. [1 ]
机构：
[1] Hosp Cent Dr Urquinaona, Serv Obstetricia Ginecol Maternidad Dr Nerio Bell, Maracaibo, Venezuela
来源：
CLINICA E INVESTIGACION EN GINECOLOGIA Y OBSTETRICIA | 2012年 / 39卷 / 05期
关键词：
Interleukin-8; Preeclampsia; Cytokines;
D O I：
10.1016/j.gine.2009.12.011
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To compare concentrations of interleukin-8 in patients with preeclampsia and healthy normotensive pregnant women. Material and methods: One hundred patients were selected. Fifty preeclamptic patients were selected as cases (group A) and 50 healthy pregnant women with a similar age and body mass index to patients in group A were selected as controls (group B). Blood samples for interleukin-8 were collected in all patients before labor and immediately after diagnosis in the study group. Results: There were no significant differences in maternal age, gestational age or body mass index at sample collection (p=ns). Statistically significant differences were found between groups in mean values of systolic and diastolic blood pressure (p<0.05). Interleukin-8 concentrations were significantly higher in group A (54.8 +/- 13.6 pg/ml) than in group B (33.6 +/- 6.3 pg/ml, p<0.05) and there was a strong, positive and significant correlation with values of systolic blood pressure (r=0.715; p<0.05) and diastolic blood pressure (r=0.640; p<0.05). Conclusion: Interleukin-8 concentrations were significantly higher in preeclamptic patients than in healthy normotensive pregnant women. (C) 2009 Elsevier Espana, S.L. All rights reserved.
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收藏
页码：182 / 186
页数：5
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