D19S51 IS CLOSELY LINKED WITH AND MAPS DISTAL TO THE MYOTONIC-DYSTROPHY LOCUS ON 19Q

被引：0

作者：

TSILFIDIS, C

MACKENZIE, AE

SHUTLER, G

LEBLOND, S

BAILLY, J

JOHNSON, K

WILLIAMSON, R

SIEGELBARTELT, J

KORNELUK, RG

机构：

[1] CHILDRENS HOSP EASTERN ONTARIO,DIV GENET,401 SMYTH RD,OTTAWA K1H 8L1,ONTARIO,CANADA

[2] UNIV OTTAWA,DEPT PEDIAT,OTTAWA K1N 6N5,ONTARIO,CANADA

[3] HOSP SICK CHILDREN,DEPT CLIN GENET,TORONTO M5G 1X8,ONTARIO,CANADA

[4] CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT,LONDON,ENGLAND

[5] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON,ENGLAND

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1991年 / 49卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent genetic linkage studies have mapped the myotonic dystrophy (DM) locus to 19ql3.3. All closely linked DM markers identified to date have been located on the centromeric side of the disease locus, with a relatively large genetic interval (9 cM) observed between the nearest distal marker and DM. We show here that the recently described marker p134C is tightly linked to DM (peak lod score 35.8 at peak recombination fraction .006) and confirm the previous suggestion that the p134C locus, D19S51 maps distal to the disease locus. D19S51 and the closest proximal flanking loci, ERCC1 and D19S115 (pE0.8), define a small genetic interval of less than 2 cM that contains the DM locus.

引用

页码：961 / 965

页数：5

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