THE EVALUATION OF THE INTERRELATION BETWEEN CHRONIC PERIODONTITIS AND CHRONIC RENAL DISEASE BY QUANTIFYING THE GLOMERULAR FILTRATION RATE MARKERS

Introduction: The latest specialty studies have demonstrated a new role of the periodontal disease in the etiopathogeny of the systemic diseases. Acute and chronic systemic infections can promote an inflammatory renal response (glomerulonephritis). Purpose of the study: The present study proposes a research of the periodontal status influence on chronic renal dysfunctions, in order to eliminate a co-factor which might affect the systemic conditions. Materials and methods: Sixty patients with incipient chronic renal disease were included in this study; they were divided in two groups (30 patients with periodontal disease and 30 patients without periodontal disease). We measured serum and urinary levels of renal function markers (urea, creatinine, albumin); glomerular filtration rate was estimated from the creatinine clearance and the changes of the albumin (mg)/creatinine (g) ratio were evaluated in the 24 hours urine sample. Results: A great number of sites with probing depth between 3 and 5mm was correlated to higher creatinine elimination rates. A high number of sites with probing depth<3mm and low bleeding on probing was associated with higher levels for creatinine, creatinine clearance and low levels of serum albumin. Conclusions: The periodontitis patients presented modifications for serum or urinary markers of renal dysfunctions, suggesting that periodontitis and periodontal treatment might influence the renal function in certain conditions.