Synthesis of anti-inflammatory furan fatty acids from biomass-derived 5-(chloromethyl)furfural

被引：16
|
作者：
Chang, Fei [1 ]
Hsu, Wan-Hsuan [2 ]
Mascal, Mark [1 ]
机构：
[1] Univ Calif Davis, Dept Chem, 1 Shields Ave, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA
来源：
SUSTAINABLE CHEMISTRY AND PHARMACY | 2015年 / 1卷
关键词：
Antioxidants; Biomass; 5-(Chloromethyl)furfural; Natural products; Synthesis;
D O I：
10.1016/j.scp.2015.09.002
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient synthetic approach to furan fatty acids starting from the biomass-derived platform chemical 5-(chloromethyl)furfural (CMF) is described. The route involves seven steps and has a 60% overall yield. Furan fatty acids are dietary antioxidants that occur naturally in fish and are proposed to have anti atherosclerotic properties. The free radical scavenging abilities of synthetic furan fatty acids were evaluated against butylated hydroxytoluene (BHT) by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：14 / 18
页数：5
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