REMARKABLE STEREOSELECTIVITY IN THE INHIBITION OF ALPHA-GALACTOSIDASE FROM COFFEE BEAN BY A NEW POLYHYDROXYPYRROLIDINE INHIBITOR

A potent inhibitor is easily accessible. The pyrrolidine derivative 1 effectively inhibits α‐galactosidase (Ki = 5 × 10−8 M), since it mimics the transition state structure of the cleavage of the glycosidic bond. Compound 1 can be prepared by chemical (see below) and chemoenzymatic routes. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany