4,4-DISUBSTITUTED PIPERIDINES - A NEW CLASS OF NK1 ANTAGONISTS

被引：0
|
作者：
STEVENSON, GI [1 ]
MACLEOD, AM [1 ]
HUSCROFT, I [1 ]
CASCIERI, MA [1 ]
SADOWSKI, S [1 ]
机构：
[1] MERCK SHARP & DOHME RES LABS,NEUROSCI RES CTR,DEPT MED CHEM,HARLOW CM20 2QR,ESSEX,ENGLAND
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 209卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：68 / MEDI
相关论文
共 50 条
  • [1] 4,4-DISUBSTITUTED PIPERIDINES - A NEW CLASS OF NK1 ANTAGONIST
    STEVENSON, GI
    MACLEOD, AM
    HUSCROFT, I
    CASCIERI, MA
    SADOWSKI, S
    BAKER, R
    JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (08) : 1264 - 1266
  • [2] 4,4-disubstituted cyclohexylamine NK1 receptor antagonists I
    Elliott, JM
    Castro, JL
    Chicchi, GG
    Cooper, LC
    Dinnell, K
    Hollingworth, GJ
    Ridgill, MP
    Rycroft, W
    Kurtz, MM
    Shaw, DE
    Swain, CJ
    Tsao, KL
    Yang, LH
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (13) : 1755 - 1758
  • [3] 4,4-disubstituted cyclohexylamine NK1 receptor antagonists II
    Cooper, LC
    Carlson, EJ
    Castro, JL
    Chicchi, GG
    Dinnell, K
    Di Salvo, J
    Elliott, JM
    Hollingworth, GJ
    Kurtz, MM
    Ridgill, MP
    Rycroft, W
    Tsao, KL
    Swain, CJ
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (13) : 1759 - 1762
  • [4] 4,4-disubstituted piperidine high-affinity NK1 antagonists:: Structure-activity relationships and in vivo activity
    Stevenson, GI
    Huscroft, I
    MacLeod, AM
    Swain, CJ
    Cascieri, MA
    Chicchi, GG
    Graham, MI
    Harrison, T
    Kelleher, FJ
    Kurtz, M
    Ladduwahetty, T
    Merchant, KJ
    Metzger, JM
    MacIntyre, DE
    Sadowski, S
    Sohal, B
    Owens, AP
    JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (23) : 4623 - 4635
  • [5] SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 4,4-DISUBSTITUTED PIPERIDINES
    COLAPRET, JA
    DIAMANTIDIS, G
    SPENCER, HK
    SPAULDING, TC
    RUDO, FG
    JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (05) : 968 - 974
  • [6] SYNTHESIS AND PHARMACOLOGICAL STUDIES OF 4,4-DISUBSTITUTED PIPERIDINES - A NEW CLASS OF COMPOUNDS WITH POTENT ANALGESIC PROPERTIES
    HUEGI, BS
    EBNOTHER, AM
    RISSI, E
    GADIENT, F
    HAUSER, D
    ROEMER, D
    HILL, RC
    BUESCHER, HH
    PETCHER, TJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (01) : 42 - 50
  • [7] Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones:: Potent NK1 antagonists
    Reichard, GA
    Stengone, C
    Paliwal, S
    Mergelsberg, I
    Majmundar, S
    Wang, C
    Tiberi, R
    McPhail, AT
    Piwinski, JJ
    Shih, NY
    ORGANIC LETTERS, 2003, 5 (23) : 4249 - 4251
  • [8] Application of the PMC protecting group in the efficient synthesis of 4,4-disubstituted piperidines
    Ralbovsky, JL
    Lisko, JG
    He, W
    SYNTHETIC COMMUNICATIONS, 2005, 35 (12) : 1613 - 1625
  • [9] Chiral separation of 4,4-disubstituted piperidinyl Substance P antagonists
    Watt, Alan P.
    Hitzel, Laure
    Journal of Liquid Chromatography and Related Technologies, 2000, 23 (16): : 2541 - 2552
  • [10] Chiral separation of 4,4-disubstituted piperidinyl substance P antagonists
    Watt, AP
    Hitzel, L
    JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2000, 23 (16) : 2541 - 2552
12345