SELENIUM COMPLEXES IN THE ANTERIOR-PITUITARY OF RATS EXPOSED TO L-SELENOMETHIONINE

被引:1
|
作者
GRONBAEK, H
THORLACIUSUSSING, O
机构
[1] Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus C
关键词
Anterior pituitary; L-Selenomethionine; Rat; Selenium;
D O I
10.1007/BF02899416
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Selenium precipitates were demonstrated histochemically by silver amplification at light and electron microscopic levels in the anterior pituitary of rats exposed to L-selenomethionine (SeMeth). By electron microscopy (EM), the silver amplified selenium complexes were identified in somatotrophs, corticotrophs and gonadotrophs. Precipitates were observed mainly in the secretory granules and to a lesser extent in the lysosomes. The staining intensity increased with increasing amounts of SeMeth. Following a single injection of 3.7 mg Se/kg a substantial increase in staining was observed during the first 48 h after injection and precipitates could still be observed in the anterior pituitary after 2 weeks. During a long-term study where the rats were exposed to selenium contained in the drinking water (3.0 mg Se/1 drinking water for 1, 2 or 4 weeks) an increasing amount of precipitates were observed during the first 2 weeks followed by a small decrease in staining intensity. Organic selenium, or rather a metabolite, is suggested to form bands with endogenous metal, primarily zinc, as has been suggested in the brain and anterior pituitary after exposure to sodium selenite. © 1990 Springer-Verlag.
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页码:291 / 296
页数:6
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