HEPATOBILIARY AND HEMATOLOGICAL EFFECTS OF DIETARY DISODIUM ARSENATE HEPTAHYDRATE IN JUVENILE RAINBOW-TROUT (ONCORHYNCHUS-MYKISS)

被引：14
|
作者：
COCKELL, KA [1 ]
HILTON, JW [1 ]
BETTGER, WJ [1 ]
机构：
[1] UNIV GUELPH,DEPT NUTR SCI,GUELPH N1G 2W1,ONTARIO,CANADA
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1992年 / 103卷 / 03期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1016/0742-8413(92)90164-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. The impact of 8-12 weeks exposure to up to 55-60 mug arsenic/g diet as disodium arsenate (DSA) on the hepatobiliary and hematological systems of rainbow trout was assessed. 2. Bile and washed gallbladder tissue arsenic residues in exposed fish were 2-4 times higher than in liver. Plasma arsenic concentration was slightly elevated following dietary DSA exposure. 3. Chronic exposure to dietary DSA caused a mild to moderate responsive anemia. 4. Lipid, but not protein, digestibility after 12 weeks of exposure showed an inverse relationship with severity of gallbladder inflammation in these fish. 5. Changes in the hepatobiliary system appear to provide the most sensitive indicators of dietary DSA exposure in rainbow trout.
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页码：453 / 458
页数：6
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