共 50 条
Formulation and In Vitro Evaluation of Mupirocin-loaded Alginate Microspheres
被引:0
|作者:
Shanmugam, V.
[1
]
Lakshmi, P. K.
[2
]
Kumar, R. V. Suresh
[3
]
机构:
[1] Jawaharlal Nehru Technol Univ, Dept Pharmaceut Sci, Kakinada, Andhra Pradesh, India
[2] G Pulla Reddy Coll Pharm, Dept Pharmaceut, Hyderabad, Telangana, India
[3] Sri Venkateswara Univ Vet Sci, Dept Surg, Tirupati, Andhra Pradesh, India
关键词:
Calcium chloride cross linking agent;
microspheres;
mupirocin;
sodium alginate;
D O I:
暂无
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Introduction: Mupirocin (pseudomonic acid A) is a topical antibiotic used for the treatment of impetigo a superficial infection of the skin. Aim: The goal of this study was to evaluate the technological feasibility of delivering antibiotic using alginate microspheres. Materials and Methods: Microspheres were prepared by emulsification method using sodium alginate as a polymer and calcium chloride (CaCl2) as a cross-linking agent. In this investigation, a novel method was used to investigate the joint influence concentration of alginate and CaCl2 in a blend of liquid paraffin in the dispersion medium. Potential variables such as the concentration of drug and sodium alginate: Drug ratios were kept constant in the experimental design. Different concentrations of the cross-linking agent and different time periods of the cross-linking process were used to change the extent of cross-linking. The cross-linked microspheres were characterized by evaluating the extent of cross-linking, the morphology, and drug loading and in vitro studies of drug release. Results and Discussion: The particle size of the drug loaded microspheres was 75 mu m, and they have narrow size distribution. Total drug loading was determined to be 15.10 +/- 0.01. Preparation process gave a yield production of nearly 80% for the prepared batches. The microspheres released 71.3% of mupirocin at 72 h. Conclusion: The study revealed that for obtaining controlled delivery of mupirocin; the microspheres should be prepared using relatively an optimum concentration of sodium alginate and CaCl2 and in the dispersion medium.
引用
收藏
页码:S320 / S323
页数:4
相关论文